485385-74-8

Basic information

• Product Name: 3-(2-ethynylphenyl)pyridine
• Synonyms: 3-(2-ethynylphenyl)pyridine
• CAS NO: 485385-74-8
• Molecular Weight: 179.221
• Mol File: 485385-74-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-ethynylphenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-ethynylphenyl)pyridine(485385-74-8)
• EPA Substance Registry System: 3-(2-ethynylphenyl)pyridine(485385-74-8)

Safety Data

• Hazardous Substances Data: 485385-74-8(Hazardous Substances Data)

Upstream product

• 4381-37-7 3-(o-chlorophenyl)pyridine 
• 626-55-1 3-Bromopyridine 

Downstream Products

• 85-02-9 benzo[f]quinoline 
• 229-71-0 benzo[h]isoquinoline 

Relevant articles and documents

Model reactions for the synthesis of azacorannulenes and related heteroaromatic compounds

4-(2-Ethynylphenyl)pyridine (10), 3-(2-ethynylphenyl)pyridine (11), 2-(2-trimethylsilylethynylphenyl)pyridine (26), and 3-ethynyl-2-phenylpyridine (13) were prepared from readily available pyridine precursors by standard coupling reactions. Pyrolysis of 10 at 810 °C/0.5 Torr provided benzo[f]isoquinoline (45) and the benzopentalene dimer 47. Pyrolysis of 11 (820 °C/0.5 Torr) afforded benzo[f]quinoline (50), benzo[h]i-soquinoline (52), and a mixture of isomers of 47. Pyrolysis of 13 (820 °C/0.3 Torr) provided benzo[h]quinoline (56) and the novel azulene derivative azuleno[1,2-b]pyridine (58). When 26 was desilylated by treatment with TBAF in THF/water, the unusual "dimerization" product 37 was produced; its structure was confirmed by X-ray structural analysis. The mechanisms of these transformations are discussed. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.