485798-62-7

Basic information

• Product Name: tert-Butyl 4-cyclobutylpiperazine-1-carboxylate
• Synonyms: tert-Butyl 4-cyclobutylpiperazine-1-carboxylate
• CAS NO: 485798-62-7
• Molecular Formula: C₁₃H₂₄N₂O₂
• Molecular Weight: 240.35
• Mol File: 485798-62-7.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 315.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.090±0.06 g/cm3(Predicted)
• PKA: 7.52±0.70(Predicted)
• CAS DataBase Reference: tert-Butyl 4-cyclobutylpiperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 4-cyclobutylpiperazine-1-carboxylate(485798-62-7)
• EPA Substance Registry System: tert-Butyl 4-cyclobutylpiperazine-1-carboxylate(485798-62-7)

Safety Data

• Hazardous Substances Data: 485798-62-7(Hazardous Substances Data)

Upstream product

• 1191-95-3 cyclobutanone 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 27374-25-0 [(1-Ethoxycyclopropyl)oxy]trimethylsilane 
• 2919-23-5 cyclobutanol 

Downstream Products

• 132800-13-6 1-cyclobutyl-piperazine 
• 1035271-09-0 ethyl 4-(4-cyclobutylpiperazin-1-yl)benzoate 
• 1000405-21-9 4-(4-cyclobutylpiperazine-1-carbonyl)benzaldehyde 

Relevant articles and documents

Pyrazolo [3,4 - the b] pyridine and [...] composition preparation method and use of (by machine translation)

The present invention provides a pyrazolo [3,4 - the b] pyridine and [...] compound of preparation and use, in particular, the present invention provides a following formula (I) compounds are shown, wherein the definition of each group as described in the specification. The compounds of the invention has excellent tyrosine kinase inhibiting activity, so can be used for preparing a series of treating diseases associated with the tyrosine kinase activity of the drug. (by machine translation)

A Survey of the Borrowing Hydrogen Approach to the Synthesis of some Pharmaceutically Relevant Intermediates

The use of the "borrowing hydrogen strategy" in the synthesis of a number of typical pharmaceutical intermediates has been investigated. The main aim of this work was to investigate the scope and limitations of current methodology using standard laboratory techniques in an industrial context. Some interesting and significant results were achieved across a diverse set of complex substrates; however several drawbacks with this approach were identified, such as the high loading, poor turnover, and susceptibility to substrate inactivation of the catalysts. These are areas which are highlighted for future investigation and improvements.

Carbamate/urea derivatives

The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.