486460-09-7

Basic information

• Product Name: BOC-D-2,4,5-TRIFLUOROPHE
• Synonyms: (R)-N-(TERT-BUTOXYCARBONYL)-2,4,5-TRIFLUOROPHENYLALANINE;BOC-D-2,4,5-TRIFLUOROPHE;BOC-D-2,4,5-TRIFLUOROPHENYLALANINE;(2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,4,5-TRIFLUOROPHENYL)PROPANOIC ACID;N-Boc-2,4,5-trifluoro-D-phenylalanine, 98%;(R)-2-((tert-Butoxycarbonyl)aMino)-3-(2,4,5-trifluorophenyl)propanoic acid;-3-(2,4,5-trifluorophenyl);Boc-(R)-2,4,5-Trifluorophenylalanine
• CAS NO: 486460-09-7
• Molecular Formula: C₁₄H₁₆F₃NO₄
• Molecular Weight: 319.28
• Product Categories: Phenylalanine analogs and other aromatic alpha amino acids
• Mol File: 486460-09-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 424.7±45.0 °C(Predicted)
• Appearance: /Solid
• Density: 1.323±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.79±0.14(Predicted)
• CAS DataBase Reference: BOC-D-2,4,5-TRIFLUOROPHE(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-2,4,5-TRIFLUOROPHE(486460-09-7)
• EPA Substance Registry System: BOC-D-2,4,5-TRIFLUOROPHE(486460-09-7)

Safety Data

• Hazardous Substances Data: 486460-09-7(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 144284-25-3 (2,4,5-trifluorophenyl)methanol 
• 486460-07-5 (2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine 
• 157911-56-3 2,4,5-trifluorobenzyl bromide 
• 486460-08-6 (R)-methyl 2-((tert-butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoate 

Downstream Products

• 654671-78-0 sitagliptin phosphate 
• 486460-25-7 [3-diazo-2-oxo-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester 
• 486460-00-8 (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid 
• 486459-71-6 Sitagliptin hydrochloride 
• 1025933-74-7 [3-oxo-3-(3-pentafluoroethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester 
• 486460-23-5 (R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate 
• 1025950-29-1 [3-(5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-3-oxo-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester 
• 486460-32-6 sitagliptin 

Relevant articles and documents

BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

FUSED TRIAZOLE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to novel fused triazole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

PIPERIDINO PYRIMIDINE DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES

The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.