4866-00-6

Basic information

• Product Name: 4-METHYL-OXAZOLE-5-CARBOXYLIC ACID AMIDE
• Synonyms: 4-METHYL-OXAZOLE-5-CARBOXYLIC ACID AMIDE;4-METHYL-1,3-OXAZOLE-5-CARBOXAMIDE;4-methyloxazole-5-carboxamide;4-Methyl-5-oxazolecarboxamide
• CAS NO: 4866-00-6
• Molecular Formula: C₅H₆N₂O₂
• Molecular Weight: 126.11
• EINECS: 225-472-7
• Mol File: 4866-00-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 260.1 °C at 760 mmHg
• Flash Point: 111.1 °C
• Appearance: /
• Density: 1.255 g/cm³
• Vapor Pressure: 0.0125mmHg at 25°C
• Refractive Index: 1.517
• CAS DataBase Reference: 4-METHYL-OXAZOLE-5-CARBOXYLIC ACID AMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-OXAZOLE-5-CARBOXYLIC ACID AMIDE(4866-00-6)
• EPA Substance Registry System: 4-METHYL-OXAZOLE-5-CARBOXYLIC ACID AMIDE(4866-00-6)

Safety Data

• Hazardous Substances Data: 4866-00-6(Hazardous Substances Data)

Usage

General Description

4-METHYL-OXAZOLE-5-CARBOXYLIC ACID AMIDE, also known as 4-methyl-5-oxazolcarboxamide, is a chemical compound with the molecular formula C5H6N2O2. It is a white solid that is used for a variety of applications in the pharmaceutical and agrochemical industries. 4-METHYL-OXAZOLE-5-CARBOXYLIC ACID AMIDE is commonly used as a building block in the synthesis of organic compounds, and it has been studied for its potential biological activities, including as an anticonvulsant and anti-inflammatory agent. Its precise uses and properties depend on the specific application and formulation in which it is used. Overall, 4-METHYL-OXAZOLE-5-CARBOXYLIC ACID AMIDE is a versatile and important chemical compound with a range of potential uses in various industries.

InChI:InChI=1/C5H6N2O2/c1-3-4(5(6)8)9-2-7-3/h2H,1H3,(H2,6,8)

Upstream product

• 20485-39-6 ethyl 4-methyloxazole-5-carboxylate 
• 1003-52-7 5-cyano-4-methyl-oxazole 
• 67983-89-5 trans-α-Chloro-β-aminocrotonamide 
• 67271-66-3 2-chloroacetoacetic acid amide 

Downstream Products

• 1003-52-7 5-cyano-4-methyl-oxazole 
• 1227077-47-5 6-methyl-2-(4-methyl-1,3-oxazol-5-yl)-5-(2-methylpropyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone 
• 106166-54-5 4-methyl-5-(4-phenyl-thiazol-2-yl)-oxazole 

Relevant articles and documents

PROCESS FOR SYNTHESIS OF 4-METHYLOXAZOLE-5-CARBOXAMIDE

The present invention provides a novel process for synthesis of 4-methyl-oxazole-5- carboxamide (OXA) which comprises reacting a compound of formula (I) with a high concentration of aqueous ammonia: (I) Wherein R1 is H or C1-10 alkyl.

Process for the manufacture of 5-cyano-4-lower alkyl-oxazoles

A process for the manufacture of a 5-cyano-4-lower alkyl-oxazole by the dehydration of a 5-carbamoyl-4-lower alkyl-oxazole is disclosed. The reaction is carried out by dehydrating the oxazole with silicon tetrachloride in the presence of an amine in an aprotic organic solvent. 5-Carbamoyl-4-methyl-oxazole may be dehydrated by the process in accordance with the invention to obtain 5-cyano-4-methyl-oxazole, which is a valuable intermediate in the synthesis of pyridoxine.