487065-36-1

Basic information

• Product Name: Acetonitrile, [(phenylmethyl)(triphenylmethyl)amino]-
• CAS NO: 487065-36-1
• Molecular Formula: C28H24N2
• Molecular Weight: 388.512
• Mol File: 487065-36-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetonitrile, [(phenylmethyl)(triphenylmethyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetonitrile, [(phenylmethyl)(triphenylmethyl)amino]-(487065-36-1)
• EPA Substance Registry System: Acetonitrile, [(phenylmethyl)(triphenylmethyl)amino]-(487065-36-1)

Safety Data

• Hazardous Substances Data: 487065-36-1(Hazardous Substances Data)

Upstream product

• 3010-05-7 benzylaminoacetonitrile 
• 76-83-5 trityl chloride 
• 100-46-9 benzylamine 

Relevant articles and documents

Diastereoselective aldolization of α-aminonitriles. Diastereoselective synthesis of β-amino alcohols and β,γ-diamino alcohols

Aldolization performed by addition of lithiated N-benzyl-N-tert-butylaminoacetonitrile to aldehydes provides diastereomerically pure anti-β-hydroxy-α-aminonitriles. They are transformed into syn,anti-protected β,γ-diamino alcohols by a two-step procedure, involving addition of a Grignard reagent and reduction. The cleavage of the N-tert-butyl group is achieved by a simple acidic treatment. The application of this methodology to chiral, nonracemic aldehydes is studied. Starting from D-isopropylideneglyceraldehyde, an anti, anti, syn, anti-(2R,3S,4S,5R,6R)-diaminotriol is prepared in acceptable yield and with a good level of diastereoselectivity.