49590-51-4Relevant articles and documents
Synthesis and structural characterization of Rh(III) complexes containing diamino ligands of types {D(C6H4NH2)2} and {D(C6H4CH2NHEt)2} (D?=?O, S) bearing different spacers
Alvarado-Rodríguez, José G.,Hernández-Balderas, Uvaldo,Andrade-López, Noemí,Salazar, Verónica,Sánchez-Cabrera, Gloria,Zuno-Cruz, Francisco J.
, p. 453 - 462 (2016)
The reaction of the diamino ligands of general formula {D(C6H4NH2)2} [D?=?O (L1); S (L2)] and {D(C6H4CH2NHEt)2} [D?=?O (L3); S (L4)] with RhCl3·3H2O yielded neutral coordination complexes [RhIII(Ln)Cl3] [n?=?1 (1); n?=?2 (2); n?=?3 (4); n?=?4 (5)]. Compound 1 in N,N-dimethylformamide solution promoted the formation of the neutral complex [RhIII(L1)(dmf)Cl3] (3). A zwitterionic complex [RhIII(HL4)Cl4] (6) was obtained from the reaction of L4with RhCl3·3H2O as a minor compound. All complexes were characterized in solution by NMR and by vibrational spectroscopy in solid state. Crystal structures of the chlorohydrates [H2L3]Cl2·H2O, [H2L4]Cl2, and the complexes 2–6 were identified by X-ray diffraction studies. Molecular structures of the complexes revealed different coordination patterns of the diamino ligands Lnas well as the formation of chelate rings of five-, six-, and eight members. The presence of N–H groups in the title compounds enhanced the formation of hydrogen bond networks that were analyzed on the basis of a graph set analysis approach, displaying rings at the first to third level.
N-Heterocyclic carbene (NHC)-catalyzed intramolecular benzoin condensation-oxidation
Satyam, Killari,Ramarao, Jakkula,Suresh, Surisetti
supporting information, p. 1488 - 1492 (2021/03/01)
NHC-Catalyzed intramolecular benzoin condensation-oxidation is developed for the expedient synthesis of diverse cyclic 1,2-diketones incorporated in dibenzo-fused seven-membered heterocycles in good to excellent yields, under ambient conditions. The prese
N-substituted nitrogen-containing heterocyclic derivative, preparation method and applications thereof
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Paragraph 0065-0067, (2019/11/20)
The invention relates to an N-substituted nitrogen-containing heterocyclic derivative, a preparation method and applications thereof. Compared with the method in prior art, the method of the present invention has the following characteristics that a series of N-substituted pyrrole or indole derivatives with novel structure and significant anticancer activity are synthesized by using a simple and effective method. According to the present invention, the MTT test results show that the derivative can significantly inhibit the proliferation activity of liver cancer cell line HepG2, lung cancer cell line A549 and other cancer cells; the N-substituted pyrrole or indole derivative containing 9,10-dihydrophenanthrene, 10,11-dihydrodibenzo[b,f]oxepin and 10,11-dihydrodibenzo[b,f]thiepin can be prepared through the one-pot reaction of dialdehyde and 4-hydroxy-L-proline or indoline-2-formic acid; and the preparation method is convenient, rapid and efficient.
Gold(I) Complexes Stabilized by Nine- and Ten-Membered N-Heterocyclic Carbene Ligands
Cervantes-Reyes, Alejandro,Rominger, Frank,Rudolph, Matthias,Hashmi, A. Stephen K.
supporting information, p. 11745 - 11757 (2019/08/20)
Nine- and ten-membered N-heterocyclic carbene (NHC) ligands have been developed and for the first time their gold(I) complexes were synthesized. The protonated NHC pro-ligands 2 a–h were prepared by the reaction of readily available N,N′-diarylformamidines with bis-electrophilic building blocks, followed by anion exchange. In situ deprotonation of the tetrafluoroborates 2 a–h with tBuOK in the presence of AuCl(SMe2) provided fast access to NHC-gold(I) complexes 3–10. These new NHC-gold(I) complexes show very good catalytic activity in a cycloisomerization reaction (0.1 mol % catalyst loading, up to 100 % conversion) and their solid-state structures reveal high steric hindrance around the metal atom (%Vbur up to 53.0) which is caused by their expanded-ring architecture.
