49592-84-9

Basic information

• Product Name: 2,5-Diaminobenzoic acid methyl ester
• Synonyms: 2,5-Diaminobenzoic acid methyl ester;Methyl 2,5-diaMinobenzoate
• CAS NO: 49592-84-9
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Mol File: 49592-84-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 334.5°C at 760 mmHg
• Flash Point: 187.3°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 0.000127mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.71±0.10(Predicted)
• CAS DataBase Reference: 2,5-Diaminobenzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Diaminobenzoic acid methyl ester(49592-84-9)
• EPA Substance Registry System: 2,5-Diaminobenzoic acid methyl ester(49592-84-9)

Safety Data

• Hazardous Substances Data: 49592-84-9(Hazardous Substances Data)

Usage

General Description

2,5-Diaminobenzoic acid methyl ester is a chemical compound that consists of a benzene ring with two amine groups (NH2) and a carboxylic acid group (COOH) at positions 2 and 5, respectively. It also contains a methyl ester group (-COOCH3), which is derived from methanol. 2,5-Diaminobenzoic acid methyl ester is commonly used in organic synthesis as a building block for various pharmaceutically active molecules and dyes. It can also act as a ligand in coordination chemistry, forming complexes with metal ions. Additionally, it has potential applications in the field of materials science and polymer chemistry due to its ability to participate in diverse chemical reactions and functionality.

InChI:InChI=1/C8H10N2O2/c1-12-8(11)6-4-5(9)2-3-7(6)10/h2-4H,9-10H2,1H3

Upstream product

• 67-56-1 methanol 
• 610-74-2 1,4-phenylenediamine-2-carboxylic acid 
• 616-79-5 2-amino-5-nitro-benzoic acid 
• 3816-62-4 5-nitroanthranilic acid methyl ester 

Downstream Products

• 77423-10-0 2,5-diaminobenzoic acid hydrazide 
• 242460-16-8 octadecanoic acid (2-hydroxymethyl-4-octadecanoylamino-phenyl)-amide 
• 860695-48-3 2,5-bis-benzenesulfonylamino-benzoic acid methyl ester 

Relevant articles and documents

Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer

Inspired by the natural product evodiamine, a novel antitumor indolopyrazinoquinazolinone scaffold was designed by scaffold hopping. Structure-activity relationship studies led to the discovery of compound 15j, which shows low nanomolar inhibitory activity against the HCT116 cell line. Further antitumor mechanism studies indicated that compound 15j acted by the dual inhibition of topoisomerase 1 and tubulin and induced apoptosis with G2 cell-cycle arrest. The quaternary ammonium salt of compound 15j (compound 15js) exhibited excellent in vivo antitumor activity (TGI = 66.6%) in the HCT116 xenograft model with low toxicity. Indolopyrazinoquinazolinone derivatives represent promising multitargeting antitumor leads for the development of novel antitumor agents.

2,4-Bis(octadecanoylamino)benzenesulfonic acid sodium salt as a novel scavenger receptor inhibitor with low molecular weight

In order to investigate the effect of the fixation of the orientations of the two long chains, three types of novel derivatives of scavenger receptor inhibitor 1 were synthesized, and their biological activities were evaluated. Among the novel derivatives