497225-66-8

Basic information

• Product Name: 5-BroMo-2-butyl-benzofuran
• Synonyms: 5-BroMo-2-butyl-benzofuran
• CAS NO: 497225-66-8
• Molecular Formula: C₁₂H₁₃BrO
• Molecular Weight: 253.13502
• Mol File: 497225-66-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 155-157 °C(Press: 9 Torr)
• Appearance: /
• Density: 1.343±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 5-BroMo-2-butyl-benzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BroMo-2-butyl-benzofuran(497225-66-8)
• EPA Substance Registry System: 5-BroMo-2-butyl-benzofuran(497225-66-8)

Safety Data

• Hazardous Substances Data: 497225-66-8(Hazardous Substances Data)

Upstream product

• 1338547-28-6 ethyl 2-(4-bromo-2-formylphenoxy)-hexanoate 
• 615-96-3 Ethyl 2-bromohexanoate 
• 1761-61-1 5-bromosalicyclaldehyde 
• 497225-62-4 2-(4-bromo-2-formylphenoxy)-hexanoic acid 

Downstream Products

• 955954-62-8 C₂₁H₂₁BrO₃ 
• 141626-36-0 dronedarone 
• 141625-93-6 dronedarone hydrochloride 
• 141626-57-5 N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide 
• 1338547-30-0 2-n-butyl-3-{4-[3-(di-n-butylamino)-propoxyl]-benzoyl}-5-bromo-benzofuran 
• 1447931-36-3 (5-bromo-2-butylbenzofuran-3-yl)-[4-(3-chloropropyl)phenyl]methanone 
• 1447931-33-0 C₂₅⁽¹⁴⁾CH₂₉ClO₄ 
• 1447931-43-2 [¹⁴C]SSR₁₄₉₇₄₄ 
• 437652-07-8 N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide 

Relevant articles and documents

PROCESS FOR PREPARING SULFONAMIDOBENZOFURAN DERIVATIVES

The invention relates to a process for preparing 5-sulfonamido-benzofuran derivatives of general formula: formula (I) in which R represents an alkyl or aryl group and R1 and R2 represent hydrogen or an alkyl or aryl group. According to the invention, the compounds of formula I are prepared by coupling a benzofuran derivative of general formula II, where X represents chlorine, bromine or iodine or a sulfonate group: formula (II) with a sulfonamide derivative of formula R—SO2—NH2, in the presence of a basic agent and of a catalyst system formed from a complex between a palladium compound and a ligand.

PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES

The present invention provides several synthetic methods for preparing N-(2-butylbenzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide, a compound of formula (3), an intermediate in the preparation of Dronedarone. The present invention further provides a process for preparing Dronedarone, comprising the steps of converting 2-butyl-5-bis(methanesulfon)-amidobenzofuran of formula (3) to Dronedarone, wherein the 2-butyl-5-bis(methanesulfon)-amidobenzofuran of formula (3) is prepared by the processes of the present invention.