49745-95-1 Usage
Description
Dobutamine hydrochloride, a dopamine derivative, is a selective β1-adrenergic agonist. It is a sympathomimetic agent with inotropic action (changes strength of muscle contraction) on the heart. However, it may have some α and β2-agonist properties as well.The active substance strengthens the contraction power of the heart, increases the stroke volume and thus the blood circulation of the organs. It is used for the treatment of acute heart failure and for cardiac stress tests.
Chemical Properties
Dobutamine hydrochloride occurs as a white to off-white crystalline powder, which is sparingly soluble in water and in alcohol. Dobutamine has a pKa of 9.4.
Uses
Different sources of media describe the Uses of 49745-95-1 differently. You can refer to the following data:
1. Dobutamine Hydrochloride is a sympathomimetic drug used to treat heart failure by inhibiting β1 receptors in the sympathetic nervous system. Cardiotonic.
2. Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects in vivo. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 ?M.
Definition
ChEBI: The hydrochloride salt of dobutamine. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used to increase the contractility of the heart in the m
nagement of acute heart failure.
Biological Activity
β 1 - and β 2 -adrenoceptor agonist with some action at the α 1 -adrenoceptor.
Biochem/physiol Actions
Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.
Pharmacokinetics
Dobutamine hydrochloride is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. It does not cause the release of endogenous norepinephrine, as does dopamine. In animal studies, dobutamine produces less increase in heart rate and less decrease in peripheral vascular resistance for a given inotropic effect than does isoproterenol.
Veterinary Drugs and Treatments
Dobutamine is used as a rapid-acting injectable positive inotropic
agent for short-term treatment of heart failure. It is also useful in
shock patients when fluid therapy alone has not restored
acceptable
arterial blood pressure, cardiac output, or tissue perfusion.
Check Digit Verification of cas no
The CAS Registry Mumber 49745-95-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,9,7,4 and 5 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 49745-95:
(7*4)+(6*9)+(5*7)+(4*4)+(3*5)+(2*9)+(1*5)=171
171 % 10 = 1
So 49745-95-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H6O2.ClH/c7-5-3-1-2-4-6(5)8;/h1-4,7-8H;1H
49745-95-1Relevant articles and documents
Synthetic method of dobutamine hydrochloride
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Paragraph 0015-0018, (2019/07/04)
The invention belongs to the field of bulk drug synthesis, and especially relates to a synthetic method of dobutamine hydrochloride. The synthetic method of dobutamine hydrochloride comprises following steps: anisyl acetone, an acid or acid hydrogenation donor, a catalyst, and 3, 4-dimethoxyphenethylamine are added into an organic solvent for mixing, reaction is carried out for 1 to 5h at 30 to 40DEG C; an obtained product is cooled to 10 to 30 DEG C through natural cooling, and filtering is carried out; the pH value of an obtained filtrate is adjusted with a 2% sodium hydroxide aqueous solution to 7 to 8, liquid separating and water washing are carried out; an obtained organic phase is added into concentrated hydrochloric acid for stirring salt forming, the organic phase is collected, and is distilled; an obtained concentrate is subjected to recrystallization in an organic solvent, and vacuum drying is carried out so as to obtain an intermediate; the intermediate is subjected to demethylating at 10 to 20 DEG C under the effect of Lewis acid, and salt forming in concentrated hydrochloric acid is carried out so as to obtain high purity dobutamine hydrochloride. The synthetic methodis capable of avoiding defects in the prior art, a novel dobutamine hydrochloride preparation method is provided, operation is simple, synthesis route is short, the synthetic method is friendly to the environment, yield is high, and cost is low.
