49763-65-7Relevant articles and documents
[closo-1-CB11H11-1-Ph]- as a structural element for ionic liquid
Jankowiak, Aleksandra,Kanazawa, Junichiro,Kaszynski, Piotr,Takita, Ryo,Uchiyama, Masanobu
, p. 195 - 200 (2013)
Ion pairs 2[Pyr] and 3[Pyr] containing [closo-1-CB11H 11-1-Ph]- as the structural element were synthesized and their liquid crystalline properties were investigated by thermal and optical methods. Their mesogenic behavior was compared to that of the analogous series 1[Pyr] having a COO linking group between the benzene ring and the cluster, and the observed structure-property relationships are discussed in the context of general trends in related non-ionic liquid crystals.
Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold
Nguyen, T. Vu,Minrovic, Bradley M.,Melander, Roberta J.,Melander, Christian
, p. 927 - 937 (2019/03/26)
Tuberculosis (TB) remains a significant global health problem for which new therapeutic options are sorely needed. The ability of the causative agent, Mycobacterium tuberculosis, to reside within host macrophages and form biofilm-like communities contributes to the persistent and drug-tolerant nature of the disease. Compounds that can prevent or reverse the biofilm-like phenotype have the potential to serve alongside TB antibiotics to overcome this tolerance, and decrease treatment duration. Using Mycobacterium smegmatis as a surrogate organism, we report the identification of two new 2-aminoimidazole compounds that inhibit and disperse mycobacterial biofilms, work synergistically with isoniazid and rifampicin to eradicate preformed M. smegmatis biofilms in vitro, are nontoxic toward Galleria mellonella, and exhibit stability in mouse plasma.
Synthesis and characterization of new nematic liquid crystalline compounds-based thiophene units
Jia, Ying-Gang,Su, Dong,Guo, Zhi-Hao,Hu, Jian-She
, p. 91 - 102 (2016/02/19)
Four new liquid crystalline thiophene compounds (M1-M4) with a long flexible spacer were prepared. Their structures were characterized by Fourier transform infrared and proton nuclear magnetic resonance. The mesomorphism and thermal stability were investigated with differential scanning calorimetry, polarizing optical microscopy, and thermogravimetric analysis. The photo-physical properties were evaluated using ultraviolet/visible spectroscopy and photoluminescence. M1-M4 all showed thermotropic mesogenic properties with excellent thermal stability, and exhibited nematic threaded texture, droplet texture, and Schlieren texture on heating and cooling cycles. The effect of flexible spacer and terminal groups on mesomorphic and spectroscopic property is discussed. The experimental results demonstrated that the tendency toward melting temperature (Tm) decreased, while isotropic temperature (Ti) increased with increasing the flexible spacer length. In CHCl3 solution, these thiophene compounds displayed an intense broad absorption band peaking within 230-340 nm and a maximum fluorescent emission wavelength at 426-439 nm.