499995-80-1

Basic information

• Product Name: (S)-BOC-BETA-TYR-OH
• Synonyms: (s)-boc-β-tyr-oh;Boc-b-Phe(4-OH)-OH;(S)-3-(Boc-amino)-3-(4-hydroxyphenyl)propionic acid, Boc-D-β-tyrosine;Boc-4-Hydroxy-L-b-phenylalanine;(S)-3-((tert-Butoxycarbonyl)amino)-3-(4-hydroxyphenyl)propanoic acid;(3S)-3-(4-hydroxyphenyl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid;(Tert-Butoxy)Carbonyl (S)-3-Amino-3-(4-hydroxy-phenyl)propionic acid
• CAS NO: 499995-80-1
• Molecular Formula: C14H19NO5
• Molecular Weight: 281.306
• Mol File: 499995-80-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 476.7±40.0 °C(Predicted)
• Appearance: /
• Density: 1.236±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.41±0.10(Predicted)
• CAS DataBase Reference: (S)-BOC-BETA-TYR-OH(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-BOC-BETA-TYR-OH(499995-80-1)
• EPA Substance Registry System: (S)-BOC-BETA-TYR-OH(499995-80-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 499995-80-1(Hazardous Substances Data)

Usage

General Description

(S)-BOC-BETA-TYR-OH is a chemical compound with the molecular formula C15H21NO5. It is an amino acid derivative that is often used in peptide synthesis. (S)-BOC-BETA-TYR-OH contains a BOC (tert-butyloxycarbonyl) protective group attached to the beta carbon, as well as a tyrosine residue. The BOC group serves to protect the amine group of the tyrosine, allowing for selective deprotection and further modifications during peptide synthesis. (S)-BOC-BETA-TYR-OH is commonly used in the pharmaceutical and biotechnology industries for the production of peptides with specific sequences and properties.

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 
• 6049-54-3 3-amino-3-(4-hydroxyphenyl)propionic acid 
• 329013-03-8 3-(4-hydroxy-phenyl)-3-phenylacetylamino-propionic acid 
• 73025-68-0 (R)-3-amino-3-(4-hydroxyphenyl)propanoic acid 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Downstream Products

• 73025-68-0 (R)-3-amino-3-(4-hydroxyphenyl)propanoic acid 

Relevant articles and documents

Resolution synthesis method of 3-amino-3-(4-hydroxyphenyl)propionic acid

The invention relates to a resolution synthesis method of 3-amino-3-(4-hydroxyphenyl)propionic acid, mainly aiming at solving the technical problems of an existing synthesis method of more steps and high cost. The resolution synthesis method comprises the following steps: enabling p-hydroxybenzaldehyde to react with ammonium acetate and malonic acid in an ethanol solution to generate a compound 1; enabling the compound 1 to react with triethylamine and di-tert-butyl dicarbonate in a mixed solution of water and acetone to generate a compound 2; enabling the compound 2 to react with R(+)-1-phenethylamine in a tetrahydrofuran solution; acidifying an intermediate product with hydrochloric acid to generate a compound 3; enabling the compound 3 to react with an ethanol solution of hydrochloric acid to obtain hydrochloride, and enabling the hydrochloride to react with a sodium hydroxide water solution to obtain a target compound 4; enabling the compound 2 to react with S-1-phenethylamine in the tetrahydrofuran solution, and acidifying an intermediate product with the hydrochloric acid to generate a compound 5; enabling the compound 5 to react with the ethanol solution of the hydrochloric acid to obtain hydrochloride and enabling the hydrochloride to react with a sodium hydroxide water solution to obtain a target compound 6. (R)- and (S)-3-amino-3-(4-hydroxyphenyl)propionic acid is widely applied in a polypeptide biopharmaceutical industry.