500547-34-2Relevant articles and documents
5-Substituted-3(2H)-furanones useful for inhibition of farnesyl-protein transferase
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, (2008/06/13)
Compounds of Formula (I): wherein R1, R2, R3, X, Y, Z and Q are as defined in the specification which compounds are inhibitors of Ras farnesyl-protein transferase enzyme (FPTase), and useful in treating ras oncogene-dependent tumors, such as cancers of the pancreas, colon, bladder, and thyroid and processes for the preparation of said compounds of Formula (I).