500576-33-0

Basic information

• Product Name: 1-(4-bromophenyl)-2-(methylsulfonyl)-1-ethanone
• Synonyms: 1-(4-bromophenyl)-2-(methylsulfonyl)-1-ethanone
• CAS NO: 500576-33-0
• Molecular Formula: C₉H₉BrO₃S
• Molecular Weight: 277.14
• Mol File: 500576-33-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 152～154℃
• Appearance: /
• CAS DataBase Reference: 1-(4-bromophenyl)-2-(methylsulfonyl)-1-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromophenyl)-2-(methylsulfonyl)-1-ethanone(500576-33-0)
• EPA Substance Registry System: 1-(4-bromophenyl)-2-(methylsulfonyl)-1-ethanone(500576-33-0)

Safety Data

• Hazardous Substances Data: 500576-33-0(Hazardous Substances Data)

Usage

Appearance

Yellow-brown solid

Usage

Commonly used in organic synthesis

Applications

Intermediate in the production of pharmaceuticals and agrochemicals

Structural features

a. Bromine atom attached to a phenyl group
b. Methylsulfonyl group attached to a 1-ethanone moiety

Research

Investigated for potential biological activities

Safety precautions

Handle with caution due to potential hazards

Versatility

Various applications in the field of chemistry

Upstream product

• 766-96-1 4-bromo-1-ethynylbenzene 
• 81585-72-0 1-(4-bromo-phenyl)-2-iodo-ethanone 
• 67-68-5 dimethyl sulfoxide 
• 99-73-0 para-bromophenacyl bromide 
• 67-71-0 dimethylsulfone 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 1861-48-9 dithiocarbonic acid S-[2-(4-bromo-phenyl)-2-oxo-ethyl] ester O-ethyl ester 
• 534-22-5 2-methylfuran 
• 2039-82-9 1-bromo-4-ethenyl-benzene 

Downstream Products

• 1599463-33-8 (Z)-N-(1-(4-bromophenyl)-2-(methylsulfonyl)vinyl)acetamide 

Relevant articles and documents

Visible-light-promoted aerobic oxidative synthesis of β-ketosulfones under photocatalyst-free conditions

A simple and convenient visible-light-mediated method has been developed for the construction of β-ketosulfones via aerobic oxidative difunctionalization of alkynes with arylazo sulfones and dioxygen in air under photocatalyst-free conditions. The present photochemical methodology provides a facile and attractive protocol to construct a series of β-ketosulfones in moderate to good yields.

Photocatalyst-Free Visible Light-Induced Synthesis of β-Oxo Sulfones via Oxysulfonylation of Alkenes with Arylazo Sulfones and Dioxygen in Air

A catalyst-free strategy has been established for the synthesis of β-oxo sulfones via visible light-induced oxysulfonylation of alkenes with arylazo sulfones with dioxygen in air. The present photoinduced transformation proceeds smoothly at room temperature in the absence of an external photosensitizer, which not only provides a mild and efficient approach to various β-oxo sulfones, but also opens a different reaction mode for the photochemical reaction of arylazo sulfones.

Nickel-Catalyzed Highly Enantioselective Hydrogenation of β-Acetylamino Vinylsulfones: Access to Chiral β-Amido Sulfones

The nickel/(S)-Binapine complex was found to be an efficient catalyst for asymmetric hydrogenation of β-acetylamino vinylsulfones to afford chiral β-Amido sulfones with excellent yields and enantioselectivities (up to 95% yields and >99% ee). This protocol has good compatibility with a series of substituted (Z)-β-acetylamino vinylsulfones or Z/E isomeric mixtures. A gram-scale reaction has also been achieved in the presence of a 0.2 mol % catalyst loading.