500900-39-0Relevant articles and documents
A novel and practical synthesis of Iclaprim
Liu, Weiyuan,Chen, Liang,Pan, Jing,Zhou, Ting,Lin, Kuaile,Zhou, Weicheng
, p. 410 - 418 (2021)
A novel and facile synthesis of Iclaprim was reported. Started from trimethoprim (TMP), the amino-protection and Friedel–Crafts acetylation with acetic anhydride were simultaneously completed in CH2Cl2 with SnCl4 as cataly
Iclaprim intermediate, and preparation method for iclaprim
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Paragraph 0114-0117; 0121-0123, (2020/02/14)
The invention discloses an iclaprim intermediate, and a preparation method for iclaprim, and provides a preparation method of a phenol compound represented by formula 8. An acetyl compound representedby formula 2 undergoes a selective demethylation reaction in an organic solvent in the presence of a Lewis acid to obtain the phenol compound of the formula 8. The invention also provides the acetylcompound of the formula 2, and a preparation method and an application thereof. The method for preparing iclaprim from the iclaprim intermediate has the advantages of economical reagents, short route,high yield, low preparation cost, simplicity in post-treatment, and suitableness for industrial production.
Iclaprim intermediate and preparation method of iclaprim
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Paragraph 0160-0163; 0167-0169, (2020/02/14)
The invention discloses an iclaprim intermediate and a preparation method of iclaprim. The invention discloses the preparation method of the iclaprim shown as a formula 7, which comprises the following steps: in an aprotic solvent, and under the action of
