500912-12-9

Basic information

• Product Name: 2-Fluoro-6-methoxybenzoyl chlorid
• Synonyms: 2-FLUORO-6-METHOXYBENZOYL CHLORIDE;Benzoyl chloride, 2-fluoro-6-methoxy- (9CI);2-Fluoro-6-methoxybenzoyl chlorid;2-(Chlorocarbonyl)-3-fluoroanisole;2-(Chlorocarbonyl)-3-fluoroanisole, 6-Fluoro-o-anisoyl chloride
• CAS NO: 500912-12-9
• Molecular Formula: C₈H₆ClFO₂
• Molecular Weight: 188.58
• Product Categories: ACIDHALIDE
• Mol File: 500912-12-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 234.9°C at 760 mmHg
• Flash Point: 100.2°C
• Appearance: /
• Density: 1.309g/cm³
• Vapor Pressure: 0.0516mmHg at 25°C
• Refractive Index: 1.523
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 2-Fluoro-6-methoxybenzoyl chlorid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-6-methoxybenzoyl chlorid(500912-12-9)
• EPA Substance Registry System: 2-Fluoro-6-methoxybenzoyl chlorid(500912-12-9)

Safety Data

• Hazard Codes: C,Xn
• Statements: 34-22
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 500912-12-9(Hazardous Substances Data)

Usage

General Description

2-Fluoro-6-methoxybenzoyl chloride is a chemical compound used in organic synthesis. It is a benzoyl chloride derivative that contains a fluoro and methoxy group, making it a useful building block for the preparation of various pharmaceuticals and agrochemicals. 2-Fluoro-6-methoxybenzoyl chlorid is a reactive acyl chloride, commonly used as a reagent for the introduction of the 2-fluoro-6-methoxybenzoyl group into organic molecules. It is also used in the production of dyes, perfumes, and other fine chemicals. Additionally, it can be used as a coupling agent in peptide chemistry for the synthesis of peptide and protein conjugates.

InChI:InChI=1/C8H6ClFO2/c1-12-6-4-2-3-5(10)7(6)8(9)11/h2-4H,1H3

Upstream product

• 137654-21-8 2-fluoro-6-methoxybenzoic acid 
• 94088-46-7 2-fluoro-6-methoxybenzonitrile 

Downstream Products

• 129103-85-1 2-Fluoro-6-methoxy-benzoic acid (3aS,8aR)-5-iodo-6-methoxy-2,3,3a,8a-tetrahydro-benzo[b]furo[3,2-d]furan-4-yl ester 
• 21793-91-9 dihydro-O-methylsterigmatocystin 
• 129103-94-2 (2-Fluoro-6-methoxy-phenyl)-(2-hydroxy-6-methoxy-phenyl)-methanone 
• 129103-96-4 (2-Fluoro-6-methoxy-phenyl)-((3aS,8aR)-4-hydroxy-6-methoxy-2,3,3a,8a-tetrahydro-benzo[b]furo[3,2-d]furan-5-yl)-methanone 
• 1516898-03-5 1-methyl-5-methoxy-2-(2'-methoxyphenyl)-4-quinolone 
• 1516898-26-2 C₁₈H₁₈FNO₃ 
• 1516898-16-0 C₁₇H₁₃FO₃ 
• 911826-36-3 4-fluorobenzofuran-3(2H)-one 
• 911826-38-5 4-fluoro-2,3-dihydrobenzofuran-3-amine 
• 6563-60-6 methoxy-9H-xanthen-9-one 
• 1532528-60-1 C₁₇H₁₉FO₃Si 
• 1532528-62-3 C₁₉H₂₃FO₅Si 
• 1516898-08-0 C₂₀H₁₄F₂N₂O₆ 

Relevant articles and documents

Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (III)

The marine natural product, marinopyrrole A (1), was previously shown to have significant antibiotic activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). Although compound (1) exhibits a significant reduction in MRSA activity in the presence of human serum, we have identified key modifications that partially restore activity. We previously reported our discovery of a chloro-derivative of marinopyrrole A (1a) featuring a 2-4 fold improved minimum inhibitory concentration (MIC) against MRSA, significantly less susceptibility to serum inhibition and rapid and concentration-dependent killing of MRSA. Here, we report a novel fluoro-derivative of marinopyrrole A (1e) showing an improved profile of potency, less susceptibility to serum inhibition, as well as rapid and concentration-dependent killing of MRSA.

An Efficient Synthesis of 1-Alkyl-2-phenyl-4-quinolones from 2-Halobenzoic Acids

-

7-Substituted Purine Derivatives for Immunosuppression

The present invention provides novel purinone and related derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formula III: