500913-24-6

Basic information

• Product Name: D-Glutamic acid, N-[[1-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]methoxyphosphinyl ]-, bis(phenylmethyl) ester
• CAS NO: 500913-24-6
• Molecular Formula: C37H39N2O8P
• Molecular Weight: 670.699
• Mol File: 500913-24-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: D-Glutamic acid, N-[[1-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]methoxyphosphinyl ]-, bis(phenylmethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: D-Glutamic acid, N-[[1-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]methoxyphosphinyl ]-, bis(phenylmethyl) ester(500913-24-6)
• EPA Substance Registry System: D-Glutamic acid, N-[[1-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]methoxyphosphinyl ]-, bis(phenylmethyl) ester(500913-24-6)

Safety Data

• Hazardous Substances Data: 500913-24-6(Hazardous Substances Data)

Upstream product

• 136516-50-2 methyl hydrogen 1-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}ethylphosphonate 
• 2791-84-6 D-glutamic acid dibenzyl ester p-toluenesufonate salt 

Downstream Products

• 500913-25-7 dibenzyl N-[[(1R,S)-1-(N-(5-phthalimidopentanoyl)amino)ethyl]methoxyphosphinyl]-D-glutamate 

Relevant articles and documents

Synthesis of new lipophilic phosphonate and phosphonamidate analogues of N-acetylmuramyl-L-alanyl-D-isoglutamine related to LK 423

A syntheses of three new muramyl dipeptide (MDP) analogues related to LK 423 as potential immunomodulators are presented. The dipeptide part of the lead compound was modified by introducing a phosphonamide isostere instead of the amide bond between L-alanine and D-glutamic acid (or D-isoglutamine), yielding new MDP analogues 5 and 9. Furthermore, the amide bond between L-Ala and D-Glu was replaced by a phosphonate isostere, giving peptidyl phosphonate 14. The scope and limitations of the synthetic strategies employed are discussed.