502-70-5Relevant articles and documents
A Short and Efficient Synthesis of Crocetin-dimethylester and Crocetindial
Frederico, Daniel,Marcos Donate, Paulo,Gomes Constantino, Mauricio,Soares Bronze, Erika,Sairre, Mirela I.
, p. 9126 - 9128 (2003)
In this paper we describe an efficient six-step synthesis of crocetin-dimethylester that could be further reduced to a "four-step" synthesis through the use of in situ procedures. The simplicity of the whole process, the ready availability of starting materials, and the high overall yield render this strategy a very attractive synthesis of this very important compound, which is the key intermediate for the synthesis of several carotenoids and other polyene natural products.
Sulfone-mediated syntheses of crocetin derivatives: Regioselectivity of highly functionalized building blocks
Oh, Eun-Taek,Kim, Young-Hun,Jin, Jingquan,Su, Liang,Seo, Jung-Ah,Koo, Sangho
, p. 4712 - 4717 (2014/06/09)
New C5 sulfone building blocks containing a masked polar end group have been devised for the efficient synthesis of carotenoids with polar termini. Chemoselectivity or the regiochemical issue of the highly functionalized units has been carefully addressed depending on the soft or hard nature of electrophiles. These building blocks have been successfully applied to the syntheses of crocetin derivatives, crocetin dial and the novel crocetin dinitrile.
METHODS FOR SYNTHESIS OF CHIRAL INTERMEDIATES OF CAROTENOIDS, CAROTENOID ANALOGS, AND CAROTENOID DERIVATIVES
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Page/Page column 47, (2010/10/20)
A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids.
