502482-25-9

Basic information

• Product Name: 2,5-Piperazinedione, 3-(2-methylpropyl)-1-(phenylmethyl)-, (3S)-
• CAS NO: 502482-25-9
• Molecular Formula: C15H20N2O2
• Molecular Weight: 260.336
• Mol File: 502482-25-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,5-Piperazinedione, 3-(2-methylpropyl)-1-(phenylmethyl)-, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Piperazinedione, 3-(2-methylpropyl)-1-(phenylmethyl)-, (3S)-(502482-25-9)
• EPA Substance Registry System: 2,5-Piperazinedione, 3-(2-methylpropyl)-1-(phenylmethyl)-, (3S)-(502482-25-9)

Safety Data

• Hazardous Substances Data: 502482-25-9(Hazardous Substances Data)

Usage

Properties

1. Chemical compound belonging to the piperazinedione class
2. Chiral molecule
3. White, crystalline solid at room temperature
4. Commonly used as a building block in organic chemistry
5. (3S)-enantiomer with specific three-dimensional arrangement of atoms

Specific content

1. Chemical compound: 2,5-Piperazinedione, 3-(2-methylpropyl)-1-(phenylmethyl)-, (3S)-
2. Class of compounds: Piperazinedione
3. Chirality: Chiral molecule with (3S)-enantiomer
4. Physical state: White, crystalline solid at room temperature
5. Usage: Building block in organic chemistry, particularly in pharmaceutical synthesis
6. Enantiomer: (3S)-enantiomer with specific biological or pharmacological effects

Upstream product

• 102115-71-9 2-chloro-N-[(S)[1-methoxycarbonyl-3-methyl] butyl] ethanamide 
• 100-46-9 benzylamine 
• 2666-93-5 (S)-Leu-OMe 
• 1373396-49-6 C₂₀H₂₈N₂O₄ 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 

Downstream Products

• 444892-03-9 (3S)-1-benzyl-3-isobutylpiperazine 

Relevant articles and documents

Structure-Activity Relationship Studies on Oxazolo[3,4- a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent in Vivo Activity

Neuropeptide S modulates important neurobiological functions including locomotion, anxiety, and drug abuse through interaction with its G protein-coupled receptor known as neuropeptide S receptor (NPSR). NPSR antagonists are potentially useful for the treatment of substance abuse disorders against which there is an urgent need for new effective therapeutic approaches. Potent NPSR antagonists in vitro have been discovered which, however, require further optimization of their in vivo pharmacological profile. This work describes a new series of NPSR antagonists of the oxazolo[3,4-a]pyrazine class. The guanidine derivative 16 exhibited nanomolar activity in vitro and 5-fold improved potency in vivo compared to SHA-68, a reference pharmacological tool in this field. Compound 16 can be considered a new tool for research studies on the translational potential of the NPSergic system. An in-depth molecular modeling investigation was also performed to gain new insights into the observed structure-activity relationships and provide an updated model of ligand/NPSR interactions.

Synthesis and structure of 1,4-dipiperazino benzenes: Chiral terphenyl-type peptide helix mimetics

(Chemical Equation Presented) The terphenyl structure has been proven to be an ideal scaffold mimicking side-chain functionalities of peptidic α-helices. The synthesis of 1,4-dipiperazino benzenes, using stepwise transition metal-catalyzed N-arylation of chiral piperazines to a central benzene core is reported. The structure determination by X-ray crystallography reveals a geometrical arrangement of the hydrophobic side chains resembling the orientation of key i, i + 3, and i + 7 positions in a peptidic α-helix or in terphenyl helix mimetics.