502509-29-7

Basic information

• Product Name: acetic acid 4-(2-{2-[5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-pyridin-2-ylmethyl ester
• CAS NO: 502509-29-7
• Molecular Weight: 634.862
• Mol File: 502509-29-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: acetic acid 4-(2-{2-[5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-pyridin-2-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: acetic acid 4-(2-{2-[5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-pyridin-2-ylmethyl ester(502509-29-7)
• EPA Substance Registry System: acetic acid 4-(2-{2-[5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-pyridin-2-ylmethyl ester(502509-29-7)

Safety Data

• Hazardous Substances Data: 502509-29-7(Hazardous Substances Data)

Upstream product

• 502509-11-7 acetic acid 4-(2-hydroxy-ethyl)-pyridin-2-ylmethyl ester 
• 502509-21-9 acetic acid 4-allyl-pyridin-2-ylmethyl ester 
• 502509-20-8 4-bromo-2-vinylpyridine 
• 192642-94-7 acetic acid 4-bromopyridin-2-ylmethyl ester 
• 131747-45-0 4-bromo-2-(hydroxymethyl)pyridine 
• 1120-87-2 4-bromopyridin 

Relevant articles and documents

Modification of the pyridine moiety of non-peptidyl indole GnRH receptor antagonists.

The synthesis of a number of indole GnRH antagonists is described. Oxidation of the pyridine ring nitrogen, combined with alkylation at the two position, led to a compound with an excellent in vitro activity profile as well as oral bioavailability in both rats and dogs.