50290-51-2

Basic information

• Product Name: Pyrimido[1,2-a]benzimidazol-4(1H)-one, 2-methyl- (9CI)
• Synonyms: Pyrimido[1,2-a]benzimidazol-4(1H)-one, 2-methyl- (9CI);2-Methyl-1H-benzo[4,5]imidazo[1,2-a]pyrimidin-4-one;2-methyl-1H-pyrimido[3,2-a]benzimidazol-4-one;2-Methyl-4-oxo-1,4a,9-triazafluorene;2-Methyl-benzo[4,5]imidazo[1,2-a]pyrimidin-4-ol;2-Methylpyrimido[1,2-a]benzimidazol-4-ol;2-Methylpyrimido[1,2-a]benzimidazole-4-ol;Pyrimido[1,2-a]benzimidazol-4-ol, 2-methyl-
• CAS NO: 50290-51-2
• Molecular Formula: C₁₁H₉N₃O
• Molecular Weight: 199.20866
• Product Categories: BENZIMIDAZOLE
• Mol File: 50290-51-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 286-288 °C(Solv: ethanol (64-17-5))
• Boiling Point: 355.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• PKA: 1.36±0.40(Predicted)
• CAS DataBase Reference: Pyrimido[1,2-a]benzimidazol-4(1H)-one, 2-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimido[1,2-a]benzimidazol-4(1H)-one, 2-methyl- (9CI)(50290-51-2)
• EPA Substance Registry System: Pyrimido[1,2-a]benzimidazol-4(1H)-one, 2-methyl- (9CI)(50290-51-2)

Safety Data

• Hazardous Substances Data: 50290-51-2(Hazardous Substances Data)

Upstream product

• 420-04-2 CYANAMID 
• 934-32-7 1H-benzimidazol-2-amine 
• 141-97-9 ethyl acetoacetate 
• 135351-18-7 1,1,1-trichloro-4-methoxy-3-penten-2-one 
• 83124-85-0 1,1,1-Trichlor-4-ethoxy-3-penten-2-on 
• 626-34-6 ethyl aminocrotonate 
• 674-82-8 4-methyleneoxetan-2-one 

Downstream Products

• 1215289-45-4 2-methyl-10-(4-methylbenzyl)-4,10-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-one 

Relevant articles and documents

Halogen-Containing 2-methylpyrimido[1,2-a]-benzimidazol-4(10H)-ones

We have synthesized a series of 3-halo-substituted pyrimidobenzimidazolones and studied the alkylation reaction of the obtained derivatives.

MRGX Receptor Antagonists

The invention relates to a method for preventing or treating a disease or disorder that is associated with the MrgX2 receptor. The invention also relates to MrgX2 antagonists and physiologically acceptable salts thereof. The invention also relates to pharmaceutical compositions and dosage forms comprising an MrgX2 antagonist.

Synthesis and characterization of some novel 2-(trifluoromethyl)pyrimido- [1,2-a]benzimidazoles and pyrimido[1,2-a]benzimidazol-2H-ones of biological interest

The synthesis of some potentially active 2-(trifluoromethyl)pyrimido [1,2-a]benzimidazoles and pyrimido[1,2-a]benzimidazol-2(1H)-ones by the cyclization of 4-alkoxyvinyl trifluoro(chloro)methyl ketones with 2-aminobenzimidazole is described. The structure