503111-24-8Relevant articles and documents
One-pot synthesis of a new series of 3-alkoxy-5-hydroxy-5-trifluoromethyl-pyrrolidin-2-ones from 1,1,1-trifluoro-4-alkoxyalk-3-en-2-ones
Zanatta, Nilo,Rosa, Luciana S.,Cortelini, Maria F. M.,Beux, Simone,Santos, Ana P. D.,Bonacorso, Helio G.,Martins, Marcos A. P.
, p. 2404 - 2408 (2002)
The synthesis of a new series of 3-alkoxy-5-hydroxy-5-trifluoromethyl pyrrolidin-2-ones 2a-h from the reaction of 1,1,1-trifluoro-4-alkoxyalk-3-en-2-ones 1a-h of the general formula F3CC(O)C(R2)=C(R1)OR, where: R = Me, Et, -(CH2)2-, -(CH2)3-; R1 = H, Me, Ph, p-Me-Ph, p-F-Ph; and R2 = H, Me, -(CH2)2-, -(CH2)3- with sodium cyanide in hydro-alcoholic medium is reported.