50332-66-6

Basic information

• Product Name: 3-NITRO-4-QUINOLINOL
• Synonyms: 4-QUINOLINOL, 3-NITRO-;4-HYDROXY-3-NITROQUINOLINE;3-NITRO-4-QUINOLINOL;3-NITRO-4-HYDROXYQUINOLINE;3-NITROQUINOLIN-4-OL;3-Nitro-4-Hydroxy quinolin;3-Nitro-4-hydroxyquinoline ,97%;4(1H)-quinolinone, 3-nitro-
• CAS NO: 50332-66-6
• Molecular Formula: C₉H₆N₂O₃
• Molecular Weight: 190.16
• Product Categories: pharmacetical;Heterocyclic Compounds;Heterocycles
• Mol File: 50332-66-6.mol
• Article Data: 23

Chemical Properties

• Melting Point: >3000C
• Boiling Point: 312.3 °C at 760 mmHg
• Flash Point: 142.7 °C
• Appearance: Tan Solid
• Density: 1.45 g/cm³
• Vapor Pressure: 0.000534mmHg at 25°C
• Refractive Index: 1.657
• Storage Temp.: Refrigerator
• Solubility: DMF (Slightly), DMSO (Slightly)
• PKA: -0.02±0.50(Predicted)
• Stability: <-200C
• CAS DataBase Reference: 3-NITRO-4-QUINOLINOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-NITRO-4-QUINOLINOL(50332-66-6)
• EPA Substance Registry System: 3-NITRO-4-QUINOLINOL(50332-66-6)

Safety Data

• Statements: 25-37-38-41
• Safety Statements: 26-36/37/39
• RIDADR: 2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 50332-66-6(Hazardous Substances Data)

Usage

Chemical Properties

Tan Solid

Uses

3-Nitro-4-hydroxyquinoline (cas# 50332-66-6) is a compound useful in organic synthesis.

InChI:InChI=1/C9H6N2O3/c12-9-6-3-1-2-4-7(6)10-5-8(9)11(13)14/h1-5H,(H,10,12)

Upstream product

• 611-36-9 quinolin-4-ol 
• 529-37-3 4(1H)-quinolinone 
• 7697-37-2 nitric acid 
• 118-92-3 anthranilic acid 
• 2099-63-0 anthranilic acid hydrochloride 
• 121845-92-9 2-<2-nitroethylideneamino>benzoic acid 
• 56-57-5 4-nitroquinoline-N-oxide 
• 108-24-7 acetic anhydride 

Downstream Products

• 103862-98-2 N-(4-hydroxyquinolin-3-yl)acetamide 
• 24220-95-9 1-Methyl-3-nitro-4-chinolon 
• 99512-72-8 3-amino-4-hydroxyquinoline 
• 39061-97-7 4-chloro-3-nitroquinoline 
• 874499-33-9 3,6-dinitro-quinolin-4-ol 
• 1382350-77-7 methyl (3-(((4-(4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl)butyl)(N,N-diethylglycyl)amino)methyl)phenyl)acetate 
• 1382350-80-2 methyl (3-(((4-(4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl)butyl)amino)methyl)phenyl)acetate 
• 1080009-67-1 methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate monosaccharin salt 
• 1080009-76-2 methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate mandelic acid salt 
• 1080009-78-4 methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate fumaric acid salt 
• 1080007-62-0 2-(4-(((3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)(1-methylpiperidin-4-yl)amino)methyl)phenyl)acetic acid 
• 1080007-89-1 methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(methylsulfonyl)acetamido)methyl)phenyl)acetate 
• 1080007-55-1 methyl 2-(3-(((3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)(1-methylpiperidin-4-yl)amino)methyl)phenyl)acetate 
• 1080007-60-8 methyl 2-(4-(((3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)(1-methylpiperidin-4-yl)amino)methyl)phenyl)acetate 

Relevant articles and documents

IMIDAZOQUINOLINE-TYPE COMPOUNDS AND USES THEREOF

Provided in the present disclosure are imidazoquinoline-type compounds, methods for their preparation, pharmaceutical compositions thereof and their use, wherein the imidazoquinoline-type compounds, upon local administration, form depots inducing cell mediated immune response while mitigating a systemic proinflammatory immune response.

LOCALLY ACTING TOLL-LIKE RECEPTOR 7 (TLR7) AND/OR TLR8 AGONIST IMMUNOTHERAPY COMPOUNDS AND THEIR USES

Provided in the present disclosure are immunotherapy compounds, pharmaceutical compositions thereof and their use, wherein the immunotherapy compounds, upon local administration, form depots inducing cell mediated immune response while mitigating a systemic proinflammatory immune response.

SUBSTITUTED IMIDAZOQUINOLINES AS AGONISTS OF TLR7

The invention relates to imidazoquinoline derivatives and to pharmaceutical compositions containing the imidazoquinoline derivatives. The imidazoquinoline derivatives of the invention are useful as toll-like receptor agonists, in particular agonists of TLR7, and promote induction of certain cytokines.