50332-68-8

Basic information

• Product Name: 2H-3,1-Benzoxazine-2,4(1H)-dione, 1-ethyl-
• Synonyms: 1-ethyl-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione;N-ethyl isatoic anhydride;N-ethylisatoic acid anhydride
• CAS NO: 50332-68-8
• Molecular Formula: C10H9NO3
• Molecular Weight: 191.186
• Mol File: 50332-68-8.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 2H-3,1-Benzoxazine-2,4(1H)-dione, 1-ethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-3,1-Benzoxazine-2,4(1H)-dione, 1-ethyl-(50332-68-8)
• EPA Substance Registry System: 2H-3,1-Benzoxazine-2,4(1H)-dione, 1-ethyl-(50332-68-8)

Safety Data

• Hazardous Substances Data: 50332-68-8(Hazardous Substances Data)

Upstream product

• 89-50-9 2-(ethylamino)benzoic acid 
• 201230-82-2 carbon monoxide 
• 91-66-7 N,N-diethylaniline 
• 613-97-8 N-methyl-N-ethylaniline 
• 118-92-3 anthranilic acid 
• 118-48-9 isatoic anhydride 
• 103-69-5 N-ethyl-N-phenylamine 
• 75-03-6 ethyl iodide 
• 75-44-5 phosgene 
• 74-96-4 ethyl bromide 

Downstream Products

• 60531-22-8 4-[2-(2-Ethylamino-benzoylamino)-ethyl]-benzoic acid 
• 52069-17-7 2-Ethylamino-N-(5-sulfamoyl-indan-2-yl)-benzamide 
• 52069-01-9 2-Ethylamino-N-[2-(4-sulfamoyl-phenyl)-ethyl]-benzamide 
• 155730-69-1 3-(2-Ethylamino-benzoylamino)-propionic acid ethyl ester 
• 1249400-33-6 C₁₂H₁₈N₂O 
• 1249561-72-5 N-butyl-2-(ethylamino)benzamide 
• 1380589-70-7 3-benzyl-1-ethyl-2,3-dihydro-2-iminoquinazolin-4(1H)-one 
• 1380589-78-5 C₁₆H₁₈N₂O 
• 1408002-59-4 C₁₆H₁₇ClN₂O 
• 1408002-60-7 C₁₆H₁₇FN₂O 
• 1251053-76-5 C₁₃H₂₀N₂O 
• 52069-18-8 C₂₅H₃₂N₄O₄S 
• 52851-60-2 ethyl 1-ethyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate 

Relevant articles and documents

Aryl or heteroaryl substituted thiadiazole compound and antibacterial application thereof

The invention belongs to the technical field of medicines, and particularly relates to an aryl or heteroaryl substituted thiadiazole compound, a preparation method and application thereof as an antibacterial drug. The compound is represented by formula (1

SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION

The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.

Synthesis and antimicrobial activity of novel 4-Hydroxy-2-quinolone analogs

Alkyl quinolone has been proven to be a privileged scaffold in the antimicrobial drug discovery pipeline. In this study, a series of new 4-hydroxy-2-quinolinone analogs containing a long alkyl side chain at C-3 and a broad range of substituents on the C-6 and C-7 positions were synthesized. The antibacterial and antifungal activities of these analogs against Staphylococcus aureus, Escherichia coli, and Aspergillus flavus were investigated. The structure-activity relationship study revealed that the length of the alkyl chain, as well as the type of substituent, has a dramatic impact on the antimicrobial activities. Particularly, the brominated analogs 3j with a nonyl side chain exhibited exceptional antifungal activities against A. flavus (half maximal inhibitory concentration (IC50) = 1.05 μg/mL), which surpassed that of the amphotericin B used as a positive control. The antibacterial activity against S. aureus, although not as potent, showed a similar trend to the antifungal activity. The data suggest that the 4-hydroxy-2-quinolone is a promising framework for the further development of new antimicrobial agents, especially for antifungal treatment.