503464-99-1

Basic information

• Product Name: 1-(2-Methoxy-5-trifluoromethylphenyl)ethanone
• Synonyms: 1-(2-Methoxy-5-trifluoromethylphenyl)ethanone;2'-Methoxy-5'-(trifluoromethyl;2'-Methoxy-5'-(trifluoromethyl)acetophenone, JRD, 97%;1-(2-Hydroxy-5-trifluoroMethyl-phenyl)-ethanone;Ethanone, 1-[2-methoxy-5-(trifluoromethyl)phenyl]-;1-(5-(trifluoromethyl)-2-methoxyphenyl)ethanone;1-(2-Methoxy-5-trifluoromethylphenyl)
• CAS NO: 503464-99-1
• Molecular Formula: C₁₀H₉F₃O₂
• Molecular Weight: 218.173
• Mol File: 503464-99-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 45-47℃
• Boiling Point: 230.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.222±0.06 g/cm3(Predicted)
• Solubility: Slightly soluble.
• CAS DataBase Reference: 1-(2-Methoxy-5-trifluoromethylphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Methoxy-5-trifluoromethylphenyl)ethanone(503464-99-1)
• EPA Substance Registry System: 1-(2-Methoxy-5-trifluoromethylphenyl)ethanone(503464-99-1)

Safety Data

• Hazardous Substances Data: 503464-99-1(Hazardous Substances Data)

Usage

Description

1-(2-Methoxy-5-trifluoromethylphenyl)ethanone is an organic compound with the molecular formula C10H9F3O2. It is a derivative of ethanone, featuring a methoxy group and a trifluoromethyl group attached to a phenyl ring. 1-(2-Methoxy-5-trifluoromethylphenyl)ethanone is known for its unique chemical properties and potential applications in various fields.

Uses

1. Used in Pharmaceutical Industry:
1-(2-Methoxy-5-trifluoromethylphenyl)ethanone is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
2. Used in Synthesis and Evaluation of Disubstituted N1and N3-Imidazolidin-2-ones:
1-(2-Methoxy-5-trifluoromethylphenyl)ethanone is used as a key component in the synthesis and evaluation of disubstituted N1and N3-Imidazolidin-2-ones. These compounds have been identified as potential immunosuppressive agents, which can be beneficial in the treatment of autoimmune diseases and organ transplantation.
3. Used in Chemical Research:
Due to its unique structure and properties, 1-(2-Methoxy-5-trifluoromethylphenyl)ethanone is also used in chemical research for studying various reaction mechanisms and exploring new synthetic pathways. This can lead to the discovery of novel compounds with potential applications in different industries.
4. Used in Material Science:
1-(2-Methoxy-5-trifluoromethylphenyl)ethanone may also find applications in material science, where its unique properties can be utilized in the development of new materials with specific characteristics, such as improved stability, reactivity, or selectivity.

Upstream product

• 402-45-9 4-hydroxybenzotrifluoride 
• 402-52-8 methyl 4-(trifluoromethyl)phenyl ether 
• 108-24-7 acetic anhydride 

Downstream Products

• 67589-15-5 1-(2-hydroxy-5-(trifluoromethyl)phenyl)ethan-1-one 
• 1345731-86-3 tert-butyl {(R)-2-[2-acetyl-4-(trifluoromethyl)phenoxy]-1-methylethyl}carbamate 
• 1345731-58-9 (3R,5S)-4-(4-chlorobenzoyl)-3,5-dimethyl-7-(trifluoromethyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine 
• 1235407-24-5 (E)-3-(dimethylamino)-1-(2-hydroxy-5-(trifluoromethyl)phenyl)prop-2-en-1-one 
• 1235407-23-4 tert-butyl 3-[5-(5-trifluoromethyl-2-hydroxyphenyl)-1H-pyrazol-1-yl]azetidine-1-carboxylate 
• 1354819-31-0 tert-butyl 3-{5-[5-trifluoromethyl-2-(2-chloro-4-{[(2,4-dimethoxybenzyl)(1,3,4-thiadiazol-5-yl)amino]sulfonyl}-5-fluorophenoxy)phenyl]-1H-pyrazol-1-yl}azetidine-1-carboxylate 
• 1354818-96-4 4-[2-(1-azetidin-3-yl-1H-pyrazol-5-yl)-5-chloro-2-fluoro-4-(trifluoromethyl)phenoxy]-N-1,3,4-thiadiazol-5-yl benzenesulfonamide 
• 1354818-97-5 5-chloro-2-fluoro-4-{4-trifluoromethyl-2-[1-(1-methylazetidin-3-yl)-1H-pyrazol-5-yl]phenoxy}-N-1,3,4-thiadiazol-ylbenzenesulfonamide 

Relevant articles and documents

Substituted Pyrrolidines and Methods of Use

The invention discloses compounds of Formula (I) wherein R1, R2, R2A, R3, R3A, R4, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

Discovery of potent selective orally active benzoxazepine-based orexin-2 receptor antagonists

During our efforts to identify a series of potent, selective, orally active human Orexin-2 Receptor (OX2R) antagonists, we elucidated structure-activity relationship (SAR) on the 7-position of a benzoxazepine scaffold by utilizing Hammett rp and Hansch-Fu

Process for producing 4-substituted benzopyran derivatives

The present invention relates to a first process for producing a 2,2-bis(fluoromethyl)-6-(perfluoroalkyl)-2H-1-benzopyran-4-carboxylic acid. The first process includes the steps of (a) reacting a 2,2-bis(fluoromethyl)-6-(perfluoroalkyl)-2H-1-benzopyran-4-