50395-70-5

Basic information

• Product Name: N,N-DIPHENYLCINNAMAMIDE
• Synonyms: N,N-DIPHENYL-CINNAMAMIDE
• CAS NO: 50395-70-5
• Molecular Formula: C₂₁H₁₇NO
• Molecular Weight: 299.36578
• Mol File: 50395-70-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 468.6°C at 760 mmHg
• Flash Point: 217.5°C
• Appearance: /
• Density: 1.167g/cm³
• Vapor Pressure: 5.9E-09mmHg at 25°C
• Refractive Index: 1.67
• CAS DataBase Reference: N,N-DIPHENYLCINNAMAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIPHENYLCINNAMAMIDE(50395-70-5)
• EPA Substance Registry System: N,N-DIPHENYLCINNAMAMIDE(50395-70-5)

Safety Data

• Hazardous Substances Data: 50395-70-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C21H17NO/c23-21(17-16-18-10-4-1-5-11-18)22(19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-17H/b17-16+

Upstream product

• 102-92-1 cinnamoyl chloride 
• 122-39-4 diphenylamine 
• 621-82-9 Cinnamic acid 
• 83-01-2 diphenylcarbamic chloride 
• 124-38-9 carbon dioxide 
• 25574-93-0 N,N-diphenyl acrylamide 
• 74-88-4 methyl iodide 
• 98-80-6 phenylboronic acid 
• 606-83-7 3,3-Diphenylpropionic acid 
• 62-53-3 aniline 
• 7474-18-2 3,3-diphenylpropanoic acid N-phenylamide 
• 519-87-9 N,N-diphenylacetamide 
• 100-52-7 benzaldehyde 
• 201230-82-2 carbon monoxide 

Downstream Products

• 103442-29-1 3,4-diphenyl-adipic acid bis-diphenylamide 
• 1075174-08-1 (E)-3-benzylidene-1-phenylindolin-2-one 
• 19621-21-7 (Z)-3-benzylidene-1-phenylindolin-2-one 
• 128316-23-4 2-benzhydryl-3-oxo-N,3-diphenylpropanamide 
• 708255-38-3 diphenyl-(6-phenyl-6,7-dihydro-5-oxa-9-aza-benzocyclohepten-8-yl)-amine 
• 37935-63-0 3,N,N-Triphenyl-3-trimethylsilanyl-propionamide 

Relevant articles and documents

Potassium Base-Catalyzed Michael Additions of Allylic Alcohols to α,β-Unsaturated Amides: Scope and Mechanistic Insights

We report herein the first KHMDS-catalyzed Michael additions of allylic alcohols to α,β-unsaturated amides through allylic isomerization. The reaction proceeds smoothly in the presence of only 5 mol% of KHMDS to afford a variety of 1,5-ketoamides in high yields. Mechanistic investigations, including experimental and computational studies, reveal that the KHMDS-catalyzed in-situ generation of the enolate from the allylic alcohol through a tunneling-assisted 1,2-hydride shift is the key to the success of this transformation. (Figure presented.).

NIS-mediated oxidative arene C(sp2)-H amidation toward 3,4-dihydro-2(1H)-quinolinone, phenanthridone, and N-fused spirolactam derivatives

A new radical-mediated intramolecular arene C(sp2)-H amidation of 3-phenylpropanamides or [1,1′-biphenyl]-2-carboxamides was developed to prepare a series of 3,4-dihydro-2(1H)-quinolinone and phenanthridone derivatives in moderate to excellent yields (33-94%). Spirolactams could also be obtained using this protocol.

SYNTHESIS OF FUNCTIONALIZED AND UNFUNCTIONALIZED OLEFINS VIA CROSS AND RING-CLOSING METATHESIS

The invention is directed to the cross-metathesis and ring-closing metathesis reactions between geminal disubstituted olefins and terminal olefins, wherein the reaction employs a Ruthenium or Osmium metal carbene complex. Specifically, the invention relates to the synthesis of alpha-functionalized or unfunctionalized olefins via intermolecular cross-metathesis and intramolecular ring-closing metathesis using a ruthenium alkylidene complex. The catalysts preferably used in the invention are of the general formulawherein:M is ruthenium or osmium;X and Xare each independently an anionic ligand;L is a neutral electron donor ligand; and,R, RR, R, R, and Rare each independently hydrogen or a substituent selected from the group consisting of C1-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, aryl, C1-C20 carboxylate, C1-C20 alkoxy, C2-C20 alkenyloxy, C2-C20 alkynyloxy, aryloxy, C2-C20 alkoxycarbonyl, C1-C20 alkylthio, C1-C20 alkylsulfonyl and C1-C20 alkylsulfinyl.