50534-45-7

Basic information

• Product Name: 1-ETHYL-PIPERIDIN-4-YLAMINE
• Synonyms: ART-CHEM-BB B016062;AKOS B016062;4-AMINO-1-ETHYL PIPERIDINE;1-ETHYL-PIPERIDIN-4-YLAMINE;1-ETHYLPIPERIDIN-4-AMINE;4-AMINO-1-ETHYL-PIPERIDINE >97%;1-Ethyl-4-aMine piperidine;1-Ethyl-4-piperidinamine
• CAS NO: 50534-45-7
• Molecular Formula: C₇H₁₆N₂
• Molecular Weight: 128.22
• Product Categories: Piperidine
• Mol File: 50534-45-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 52-54°C/46mm
• Flash Point: 50.2 °C
• Appearance: /
• Density: 0.898 g/cm³
• Vapor Pressure: 2.48mmHg at 25°C
• Refractive Index: 1.4725 (589.3 nm 19.5℃)
• PKA: 10.50±0.20(Predicted)
• CAS DataBase Reference: 1-ETHYL-PIPERIDIN-4-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ETHYL-PIPERIDIN-4-YLAMINE(50534-45-7)
• EPA Substance Registry System: 1-ETHYL-PIPERIDIN-4-YLAMINE(50534-45-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 50534-45-7(Hazardous Substances Data)

Usage

General Description

1-ETHYL-PIPERIDIN-4-YLAMINE is a chemical compound with the molecular formula C9H18N. It is a tertiary amine derivative of piperidine, containing an ethyl group attached to the nitrogen atom of the piperidine ring. This chemical is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and fine chemicals. Its unique structure and reactivity make it valuable for the production of diverse organic compounds. Additionally, 1-ETHYL-PIPERIDIN-4-YLAMINE is also employed as an intermediate in the manufacturing of surfactants, antioxidants, and dyes. Overall, this chemical has versatile applications and plays a crucial role in the production of numerous commercial products.

InChI:InChI=1/C7H16N2/c1-2-9-5-3-7(8)4-6-9/h7H,2-6,8H2,1H3

Upstream product

• 182223-54-7 piperidin-4-ylcarbamic acid benzyl ester 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 220394-97-8 4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)piperidine 
• 99329-51-8 ethyl 1-ethyl-4-oxopiperidine-3-carboxylate 
• 3612-18-8 N-ethyl-4-piperidone 

Downstream Products

• 1001347-15-4 4-amino-3-chloro-N-(1-ethyl-4-piperidyl)benzamide 
• 1001347-08-5 4-amino-N-(1-ethyl-4-piperidyl)-2-fluoro-5-methoxy-benzamide 
• 1229021-65-1 C₂₄H₂₅N₅O 
• 1179265-01-0 4-amino-N-(1-ethyl-piperidin-4-yl)-benzamide 
• 1201693-09-5 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(1-ethyl-piperidin-4-yl)-2,3-difluoro-benzamide 
• 1201692-99-0 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(1-ethyl-piperidin-4-yl)-2,5-difluoro-benzamide 
• 1201692-81-0 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-ethoxy-N-(1-ethyl-piperidin-4-yl)-benzamide 
• 1201692-73-0 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(1-ethyl-piperidin-4-yl)-3-trifluoromethyl-benzamide 
• 1201692-65-0 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-ethyl-N-(1-ethyl-piperidin-4-yl)-benzamide 
• 1201692-57-0 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(1-ethyl-piperidin-4-yl)-3-methyl-benzamide 
• 1201692-89-8 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(1-ethyl-piperidin-4-yl)-3-fluoro-benzamide 
• 1001346-95-7 4-amino-N-(1-ethyl-piperidin-4-yl)-3-methoxy-benzamide 
• 1201692-55-8 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-2-fluoro-5-methoxy-N-(1-ethyl-piperidin-4-yl)-benzamide 
• 1137867-41-4 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(1-ethyl-piperidin-4-yl)-3-methoxy-benzamide 

Relevant articles and documents

Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in?vivo anti-tumor activity

Novel 1H-benzo[d]immidazole-4-carboxamide derivatives bearing five-membered or six-membered N-heterocyclic moieties at the 2-position were designed and synthesized as PARP-1 inhibitors. Structure-activity relationships were conducted and led to a number of potent PARP-1 inhibitors having IC50 values in the single or double digit nanomolar level. Some potent PARP-1 inhibitors also had similar inhibitory activities against PARP-2. Among all the synthesized compounds, compound 10a and 11e displayed strong potentiation effects on temozolomide (TMZ) in MX-1?cells (PF50?=?7.10, PF50?=?4.17). In?vivo tumor growth inhibition was investigated using compound 10a in combination with TMZ, and it was demonstrated that compound 10a could strongly potentiate the cytotoxicity of TMZ in MX-1 xenograft tumor model. Two co-crystal structures of compounds 11b and 15e complexed with PARP-1 were achieved and demonstrated a unique binding mode of these benzo-imidazole derivatives.

TROPANE COMPOUNDS

A compound according to Formula I or II: (I) or (II) wherein R1, R1b, R2, L1, and L2 and L2b are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.

ALKYLCARBAMOYL NAPHTHALENYLOXY- OCTENOYLHYDROXYAMIDE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PREPARATION THEREOF

This invention discloses a novel alkylcarbamoyl naphthalenyloxy octenoylhydroxyamide derivative of formula (1) useful for inhibiting the enzyme activity of histone deacetylase, which leads to effective suppression of the cancer cell proliferation, a method for preparing same and a pharmaceutical composition comprising same.