50534-49-1

Basic information

• Product Name: 3-DIMETHYLAMINOPIPERIDINE
• Synonyms: 3-DIMETHYLAMINOPIPERIDINE;CHEMBRDG-BB 4018212;N,N-DIMETHYLPIPERIDIN-3-AMINE;3-DIMETHYLAMINO-PIPERIDINE >98%;N,N-dimethylpiperidin-3-amine(SALTDATA: 2HCl);DIMETHYLAMINOPIPERIDINE;3-PiperidinaMine,N,N-diMethyl-;DiMethyl-piperidin-3-yl-aMine
• CAS NO: 50534-49-1
• Molecular Formula: C₇H₁₆N₂
• Molecular Weight: 128.22
• Product Categories: Piperidine
• Mol File: 50534-49-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 58°C/7mm
• Flash Point: 65.171 °C
• Appearance: /
• Density: 0.912 g/cm³
• Vapor Pressure: 0.836mmHg at 25°C
• Refractive Index: 1.479
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.83±0.10(Predicted)
• CAS DataBase Reference: 3-DIMETHYLAMINOPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-DIMETHYLAMINOPIPERIDINE(50534-49-1)
• EPA Substance Registry System: 3-DIMETHYLAMINOPIPERIDINE(50534-49-1)

Safety Data

• Hazardous Substances Data: 50534-49-1(Hazardous Substances Data)

Usage

General Description

3-Dimethylaminopiperidine is a chemical compound with the molecular formula C8H17N. It is a colorless to pale yellow liquid with a faint amine odor. This chemical is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of rubber accelerators, corrosion inhibitors, and surfactants. Additionally, 3-Dimethylaminopiperidine is utilized as a catalyst in organic reactions and as a reagent in the synthesis of dyes and pigments. It is considered to be a hazardous chemical and proper precautions should be taken when handling and storing it.

InChI:InChI=1/C7H16N2/c1-9(2)7-4-3-5-8-6-7/h7-8H,3-6H2,1-2H3

Upstream product

• 1000576-83-9 tert-butyl 3-(dimethylamino)piperidinyl-1-carboxylate 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 60717-46-6 (1-benzyl-piperidin-3-yl)-dimethyl-amine 

Relevant articles and documents

SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1

The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): (Iar) wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Pyrazine derivatives

Pyrazine derivatives by the formula STR1 are disclosed. In the above formula, R1 and R2, which may be the same or different, each represents a hydrogen atom, a halogen atom, a hydroxy group, a lower alkoxy group, a phenyl lower alkoxy group, a phenoxy group, a mercapto group, a lower alkylthio group, a phenyl lower alkylthio group, a phenylthio group, an amino group, a substituted amino group, a lower alkyl group, a carbamoyl group or a sulfamoyl group; R3 represents a lower alkoxy group; R4, R5, and R6, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, a phenyl lower alkyl group, or a phenyl group; and A represents a lower alkylene group; said R4 and A, said R5 and A, said R4 and R5, or said R5 and R6 may form a 5-membered or 6-membered nitrogen-containing heterocyclic ring which may further contain a hetero-atom together with nitrogen atom, and the pharmacologically acceptable non-toxic salts thereof. The compounds of this invention have a strong and selective antiematic activity and an effect of stimulating the gastric motility.