5055-72-1

Basic information

• Product Name: 1-CYCLOHEXYL-2-THIOUREA
• Synonyms: CYCLOHEXYL-THIOUREA;1-CYCLOHEXYL-2-THIOUREA;N-CYCLOHEXYLTHIOUREA;1-cyclohexyl-2-thio-ure;Urea, 1-cyclohexyl-2-thio-;1-Cyclohexylthiourea
• CAS NO: 5055-72-1
• Molecular Formula: C₇H₁₄N₂S
• Molecular Weight: 158.26
• Mol File: 5055-72-1.mol
• Article Data: 27

Chemical Properties

• Melting Point: 162 °C
• Boiling Point: 260.4°C at 760 mmHg
• Flash Point: 111.3°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 0.0123mmHg at 25°C
• Refractive Index: 1.566
• PKA: 14.58±0.20(Predicted)
• CAS DataBase Reference: 1-CYCLOHEXYL-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CYCLOHEXYL-2-THIOUREA(5055-72-1)
• EPA Substance Registry System: 1-CYCLOHEXYL-2-THIOUREA(5055-72-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RTECS: YS7700000
• HazardClass: IRRITANT
• Hazardous Substances Data: 5055-72-1(Hazardous Substances Data)

Usage

General Description

1-Cyclohexyl-2-thiourea, also known as CTU, is an organic compound that is derived from thiourea. It is a white crystalline solid that is soluble in water and polar organic solvents. CTU has been primarily used as a rubber accelerator in the vulcanization process of rubber production. It acts as a catalyst in the crosslinking of rubber molecules, leading to improved strength and elasticity of the final rubber product. Additionally, 1-Cyclohexyl-2-thiourea has also been employed in the synthesis of pharmaceuticals, as a corrosion inhibitor, and in the treatment of metal surfaces. It is important to handle this compound with care, as it can be hazardous to health and the environment if not properly managed.

InChI:InChI=1/C7H14N2S/c8-7(10)9-6-4-2-1-3-5-6/h6H,1-5H2,(H3,8,9,10)

Upstream product

• 931-53-3 Cyclohexyl isocyanide 
• 108-91-8 cyclohexylamine 
• 17356-08-0 thiourea 
• 13037-17-7 Cyclohexyldithiocarbamidsaeure-methylester 
• 4921-92-0 TM-2-97 
• 3173-53-3 Cyclohexyl isocyanate 
• 43009-21-8 Cyclohexyl-dithiocarbamic acid; compound with triethyl-amine 
• 98-88-4 benzoyl chloride 
• 88-75-5 2-hydroxynitrobenzene 
• 591-27-5 m-Hydroxyaniline 
• 156-43-4 4-Ethoxyaniline 
• 95-55-6 2-amino-phenol 
• 1212-29-9 1,3-dicyclohexylthiourea 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 34631-45-3 cyclohexyl-(4-ethyl-thiazol-2-yl)-amine 
• 84669-95-4 3-Bromo-3-methyl-2-oxo-azetidine-1-carbothioic acid cyclohexylamide 
• 1505453-00-8 3-cyclohexyl-2-imino-5-phenyl-5-[3-(pyridin-3-yl)phenyl]imidazolidin-4-one 
• 36997-96-3 N-acetyl-N'-cyclohexyl-thiourea 
• 189572-02-9 tert-butyl N-(cyclohexylcarbamothioyl)carbamate 
• 102936-63-0 2'-phenylimidazo<1,2-a>pyridin-3'-ylimino-4-thiazolidinone 
• 27052-19-3 2-cyclohexylimino-4-thiazolidinone 
• 79615-56-8 {4-[4-(4-Chloro-benzyloxy)-phenyl]-thiazol-2-yl}-cyclohexyl-amine 
• 111504-40-6 5-bromoethyl-2-cyclohexylaminothiazol-4(5H)-one 
• 111504-33-7 2-cyclohexylaminothiazole-5-spirocyclopropan-4(5H)-one 
• 111504-32-6 7-Bromo-3-cyclohexyl-4-thioxo-3,5-diaza-tricyclo[5.2.2.0^1,5]undecane-2,6-dione 
• 126567-63-3 C₂₁H₂₄FN₃OS 
• 84669-88-5 3,3-Dimethyl-2-oxo-azetidine-1-carbothioic acid cyclohexylamide 
• 84669-89-6 3-(3-Cyclohexyl-thioureido)-2,2-dimethyl-propionic acid 

Relevant articles and documents

Iron-mediated desulphurization approach: synthesis of cyanamides and their conversions

The iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology. All the reactions are rapid, facile, and accomplished at room temperature. A variety of substrates readily underwent the optimized reaction conditions to provide their respective target products in good to excellent yields. Furthermore, we have confirmed that no other by-products could be identified during our experimental reaction process. Graphical abstract: Iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology.[Figure not available: see fulltext.].

Green and efficient synthesis of thioureas, ureas, primary: O -thiocarbamates, and carbamates in deep eutectic solvent/catalyst systems using thiourea and urea

An efficient and general catalysis process was developed for the direct preparation of various primary O-thiocarbamates/carbamates as well as monosubstituted thioureas/ureas by using thiourea/urea as biocompatible thiocarbonyl (carbonyl) sources. This procedure used choline chloride/tin(ii) chloride [ChCl][SnCl2]2 with a dual role as a green catalyst and reaction medium to afford the desired products in moderate to excellent yields. Moreover, the DES can be easily recovered and reused for seven cycles with no significant loss in its activity. Besides, the method shows very good performance for synthesizing the desired products on a large scale.

Cobalt-promoted one-pot reaction of isothiocyanates toward the synthesis of aryl/alkylcyanamides and substituted tetrazoles

[Figure not available: see fulltext.] The synthesis of cyanamides and tetrazoles from isothiocyanates through tandem reaction using cobalt catalyst has been demonstrated. In the case of tetrazole preparation, the reaction involved addition/desulfurization/nucleophilic addition/electrocyclization, whereas aromatic cyanamides were constructed from isothiocyanates through addition/desulfurization. Cheap cobalt sulfate was used for the synthesis of various cyanamides and tetrazoles. In addition, cobalt catalyst was found to be desulfurization reagent that has not been previously reported. The final products have been obtained from starting precursors in good to high yield.