50551-10-5Relevant articles and documents
Synthesis and molecular modeling of 1H-pyrrolopyrimidine-2,4-dione derivatives as ligands for the α1-adrenoceptors
Pittalà, Valeria,Siracusa, Maria A.,Modica, Maria N.,Salerno, Loredana,Pedretti, Alessandro,Vistoli, Giulio,Cagnotto, Alfredo,Mennini, Tiziana,Romeo, Giuseppe
experimental part, p. 5260 - 5276 (2011/10/02)
Three different series of 1H-pyrrolopyrimidine-2,4-dione derivatives were designed and synthesized as ligands for the α1-adrenergic receptors (α1-ARs). A microwave-assisted protocol was developed in order to improve purity and yields
3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective α1- adrenoceptor ligands
Pittala, Valeria,Romeo, Giuseppe,Salerno, Loredana,Siracusa, Maria Angela,Modica, Maria,Materia, Luisa,Mereghetti, Ilario,Cagnotto, Alfredo,Mennini, Tiziana,Marucci, Gabriella,Angeli, Piero,Russo, Filippo
, p. 150 - 153 (2007/10/03)
The discovery of a new series of selective and high-affinity α1-adrenoceptor (α1-AR) ligands, characterized by a 1H-pyrrolo[2,3-d]-pyrimidine-2,4(3H,7H)-dione system, is described in this paper. Some synthesized compounds, including 20, 22, and 30, displayed affinity in the nanomolar range for α1-ARs and substantial selectivity with respect to 5-HT1A and dopaminergic D1 and D 2 receptors. Functional assays, performed on selected derivatives, showed antagonistic properties.