5056-07-5

Basic information

• Product Name: (S)-(-)-METHYL P-TOLYL SULFOXIDE
• Synonyms: (S)-(-)-METHYL P-TOLYL SULFOXIDE;(S)-(-)-METHYL P-TOLYL SULFOXIDE, 99% (9;(S)-Methyl 4-tolyl sulfoxide;(S)-Methyl p-methylphenyl sulfoxide;(S)-p-Methylphenyl methyl sulfoxide;(S)-p-Tolyl methyl sulfoxide;1-Methyl-4-[(S)-methylsulfinyl]benzene;S-(4-Methylphenyl) methyl sulfoxide
• CAS NO: 5056-07-5
• Molecular Formula: C₈H₁₀OS
• Molecular Weight: 154.23
• Product Categories: Chiral Compound;Chiral Building Blocks;Organic Building Blocks;Sulfoxides
• Mol File: 5056-07-5.mol
• Article Data: 176

Chemical Properties

• Melting Point: 75-77 °C(lit.)
• Boiling Point: 282.403°C at 760 mmHg
• Flash Point: 124.593°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.59
• BRN: 2324696
• CAS DataBase Reference: (S)-(-)-METHYL P-TOLYL SULFOXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-METHYL P-TOLYL SULFOXIDE(5056-07-5)
• EPA Substance Registry System: (S)-(-)-METHYL P-TOLYL SULFOXIDE(5056-07-5)

Safety Data

• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 5056-07-5(Hazardous Substances Data)

Usage

Uses

(S)-(-)-Methyl p-tolyl sulfoxide can be used as a nucleophilic reagent to synthesize: Optically active β-disulfoxides by reacting with arenesulfinic esters via formation of α-sulfinylcarbanion. α-substituted N-hydroxylamines by treating with nitrones via preparation of (S)-(-)-methyl p-tolyl sulfoxide anion. 2-O-benzyl-3,4-O-isopropylidene-L-erythrose by one-carbon homologation of 2,3-O-isopropylidene-L-glyceraldehyde.

InChI:InChI=1/C8H10OS/c1-7-3-5-8(6-4-7)10(2)9/h3-6H,1-2H3/t10-/m1/s1

Upstream product

• 623-13-2 4-methylphenyl methylsulfide 
• 31350-91-1 (R)-chloromethyl p-tolyl sulfoxide 
• 917-64-6 methyl magnesium iodide 
• 169330-85-2 (+)-(S)-N-propanoyl-N-benzyl-p-toluenesulfinamide 
• 75-16-1 methylmagnesium bromide 
• 158109-78-5 (R,E)-N-benzylidene-4-methylbenzenesulfinamide 
• 170956-16-8 4-Methyl-benzenesulfinic acid 1-naphthalen-1-yl-meth-(E)-ylideneamide 
• 929274-19-1 (R)-(-)-N-(4-methoxybenzylidene)-p-toluenesulfonamide 
• 350479-90-2 (S,E)-N-benzylidene-4-methylbenzenesulfinamide 
• 934-72-5 Methyl p-tolyl sulfoxide 
• 676-58-4 methylmagnesium chloride 
• 859-97-2 3,7-diketocholanic acid 
• 6929-22-2 3,6-dioxocholanoic acid 
• 850175-18-7 3-[(4-methylphenyl)sulfinyl]propanoic acid ethyl ester 

Downstream Products

• 142722-58-5 (S)-(-)-1-fluoro-3-<(4-methylphenyl)sulphinyl>propan-2-one 
• 131617-81-7 (-)-(S)-5-Methyl-1-(p-tolylsulfinyl)-5-hexen-2-one 
• 155671-28-6 (S)-3-(2-Methoxy-ethoxymethoxy)-1-((S)-toluene-4-sulfinyl)-butan-2-one 
• 90988-94-6 (4S,6S)-4-(2-Benzyloxy-ethyl)-2,2-dimethyl-6-[2-((S)-toluene-4-sulfinyl)-ethyl]-[1,3]dioxane 
• 155671-29-7 (S)-1-Methoxymethoxy-1-phenyl-3-((S)-toluene-4-sulfinyl)-propan-2-one 
• 24824-93-9 chloromethyl p-tolyl sulfoxide 
• 112373-72-5 (S)-(E)-2-(p-Toluenesulfinyl)vinyl methanesulfonate 
• 104891-35-2 (S)-(-)-1-chloro-3-<(4-methylphenyl)sulphinyl>propan-2-one 
• 24702-26-9 S-p-Tolyl-S-methyl-N-p-tosylsulfimid 
• 121911-13-5 (4S,5R)-4-fluoro-5-hydroxy-6-<(S)-(4-methylphenyl)sulfinyl>hex-1-ene 
• 253608-99-0 1,1,1-Trifluoro-3-((S)-toluene-4-sulfinyl)-propan-2-one 
• 371258-84-3 (S)-1-[2-hydroxy-4,6-dimethoxy-3-(2-propen-1-yl)-2-(4-methylphenylsulfinyl)]ethanone 
• 561276-75-3 (-)-(E,R_S)-1-(p-tolylsulfinyl)-4-methoxy-3-heptene-2-one 

Relevant articles and documents

Diketobile acids as new hosts in solid-state enantioselective resolutions

New diketobile acid derivatives have been evaluated as hosts in the resolution of aryl methyl sulfoxides. The guest molecules are linked to the host ones via hydrogen bonds with the SO group. The 3,6-diketo derivative is also effective for the resolution of γ-lactames. Copyright

Highly Efficient Access to (S)-Sulfoxides Utilizing a Promiscuous Flavoprotein Monooxygenase in a Whole-Cell Biocatalyst Format

Chiral sulfoxides have gained attention as synthons and precursors for API synthesis. Flavoproteins such as Baeyer-Villiger or styrene monooxygenases mainly provide access to (R)-sulfoxides and often suffer from low selectivity, activity, and/or limited substrate scope. The flavoprotein monooxygenase AbIMO from Acinetobacter baylyi ADP1 initiates indole degradation. Here, AbIMO was expressed recombinantly in E. coli and characterized for its sulfoxidation activity and substrate spectrum. Next to indole and styrene, AbIMO was found to accept numerous alkyl aryl sulfides as substrates, transforming them to (S)-sulfoxides with high enantioselectivity (95 percent to '99 percent for most sulfides). The formulation as a whole-cell biocatalyst allowed specific production rates of up to 370 U gcdw?1 – the highest specific oxygenase activity achieved in whole cells so far – and the preparative synthesis of enantiopure (S)-aryl alkyl sulfoxides. With its extraordinarily high specific activity, high specificity, ease of handling, and high stability (catalyst is stable for '16 days at 4 °C), the designed whole-cell biocatalyst adds enormous value to the portfolio of chemical and biological catalysts for asymmetric sulfoxide synthesis.

Enzymatic kinetic resolution of chiral sulfoxides-an enantiocomplementary approach

A new enzymatic assay for the preparation of chiral sulfoxides that is enantiocomplementary to the known (S)-enantiomer-reducing activity of methionine sulfoxide reductase A (MsrA) is described. To this end, we have utilized the enzyme DMSO reductase (DmsABC), recently discovered by us being highly upregulated in stationary phase E. coli bacteria.