5056-80-4

Basic information

• Product Name: 1,2,3,4-Tetrahydro-6-methoxy-2-[(4-methoxyphenyl)methyl]isoquinolin-7-ol
• Synonyms: 1,2,3,4-Tetrahydro-6-methoxy-2-[(4-methoxyphenyl)methyl]isoquinolin-7-ol;Sendaverine;6-Methoxy-2-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-7-ol
• CAS NO: 5056-80-4
• Molecular Formula: C₁₈H₂₁NO₃
• Molecular Weight: 299.36
• Mol File: 5056-80-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2,3,4-Tetrahydro-6-methoxy-2-[(4-methoxyphenyl)methyl]isoquinolin-7-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-Tetrahydro-6-methoxy-2-[(4-methoxyphenyl)methyl]isoquinolin-7-ol(5056-80-4)
• EPA Substance Registry System: 1,2,3,4-Tetrahydro-6-methoxy-2-[(4-methoxyphenyl)methyl]isoquinolin-7-ol(5056-80-4)

Safety Data

• Hazardous Substances Data: 5056-80-4(Hazardous Substances Data)

Usage

Chemical class

Tetrahydroisoquinoline derivative

1,2,3,4-Tetrahydro

Four hydrogen atoms added to the isoquinoline ring

6-Methoxy

A methoxy group (-OCH3) at the 6th position

2-[(4-Methoxyphenyl)methyl]

A 4-methoxyphenylmethyl group (-CH2-4-methoxyphenyl) at the 2nd position

7-Ol

A hydroxyl group (-OH) at the 7th position

Research purposes

Used in pharmaceutical and medicinal chemistry

Biological activities

May have potential due to its unique structure

Further research

Required to fully understand its potential applications and effects

Upstream product

• 15357-97-8 O-benzylsendaverine 
• 81782-27-6 N-(3-benzyloxy-4-methoxybenzyl)-N-(4-methoxybenzyl)aminoacetaldehyde 
• 84268-62-2 N-(3-benzyloxy-4-methoxybenzyl)-N-4-methoxybenzylaminoacetaldehyde diethyl acetal 
• 84268-60-0 N-(3-benzyloxy-4-methoxybenzyl)-4-methoxybenzylamine 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 
• 100-07-2 4-methoxy-benzoyl chloride 
• 91586-27-5 6-(4-Methoxy-benzoyl)-2-oxo-5,6,7,8-tetrahydro-2H-pyrano[3,2-c]pyridine-3-carboxylic acid methyl ester 
• 91586-45-7 6-Methoxy-2-(4-methoxy-benzoyl)-1,2,3,4-tetrahydro-isoquinoline-7-carboxylic acid 
• 91586-46-8 6-Methoxy-2-(4-methoxy-benzoyl)-1,2,3,4-tetrahydro-isoquinoline-7-carbonyl chloride 
• 91586-29-7 Methyl 6-methoxy-2-(4-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylate 
• 91586-44-6 7-Acetyl-6-methoxy-2-(4-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline 
• 190012-08-9 1-(4-methoxybenzoyl)-4-piperidone ethylene ketal 
• 91586-26-4 1-(4-methoxybenzoyl)piperidin-4-one 
• 3717-21-3 p-methoxyl benzaldoxime 

Relevant articles and documents

N-BENZYLISOQUINOLINE ALKALOIDS FROM CERATOCAPNOS HETEROCARPA

Three new N-benzylisoquinoline alkaloids, namely isosendaverine, capnosine and capnosinine, were isolated from Ceratocapnos heterocarpa in addition to the known sendaverine.Their structure was established by spectroscopic methods and verified by total synthesis.

Inverse Electron Demand Diels-Alder Reactions of 3-Carbomethoxy-2-pyrones. Controlled Introduction of Oxygenated Aromatics: Benzene, Phenol, Catechol, Resorcinol, and Pyrogallol Annulation. Regiospecific Total Synthesis of Sendaverine and a Preparation of 6,7-Benzomorphans

A full investigation of the preparation and Diels-Alder reactions of 3-carbomethoxy-2-pyrones is described.Methods for the preparation of a full range of oxygen-substituted aromatics: benzene, 1-, 2-, or 3-phenol, symmetrical or unsymmetrical o-catechol, resorcinol, and pyrogallol annulation from a common 3-carbomethoxy-2-pyrone intermediate are detailed.A regiospecific total synthesis of sendaverine, a 2-benzyltetrahydroisoquinoline possessing a selectively protected, symmetrical o-catechol, and a preparation of 6,7-benzomorphans are described.

A Novel Synthesis of the 2-Benzylisoquinoline Alkaloids, Sendaverine and Corgoine, with Aziridinium Salts as Reactive Intermediates

A total synthesis of the 2-benzylisoquinoline alkaloids sendaverine (1) and corgoine (2) has been achieved by employing the ring-opening reaction of aziridinium salts as a key step.