5057-12-5

Basic information

• Product Name: 4,6,7,8-TETRAHYDRO-1H,3H-QUINOLINE-2,5-DIONE
• Synonyms: 3,4,7,8-Tetrahydroquinoline-2,5(1H,6H);4,6,7,8-TETRAHYDRO-1H,3H-QUINOLINE-2,5-DIONE;4,6,7,8-TETRAHYDRO-2,5(1H,3H)-QUINOLINEDIONE;4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione;1,3,4,6,7,8-hexahydroquinoline-2,5-quinone;2,5-Dioxo-1,2,3,4,5,6,7,8-octahydroquinoline;3,4,7,8-Tetrahydroquinoline-2,5(1H,6H)-dione;4,6,7,8-Tetrahydro-3,4,5,6,7,8-hexahydrocarbostyril-5-one
• CAS NO: 5057-12-5
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• Product Categories: Heterocycles
• Mol File: 5057-12-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 196-198°C
• Boiling Point: 411.4 °C at 760 mmHg
• Flash Point: 197.2 °C
• Appearance: /
• Density: 1.22 g/cm³
• Vapor Pressure: 5.6E-07mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4,6,7,8-TETRAHYDRO-1H,3H-QUINOLINE-2,5-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6,7,8-TETRAHYDRO-1H,3H-QUINOLINE-2,5-DIONE(5057-12-5)
• EPA Substance Registry System: 4,6,7,8-TETRAHYDRO-1H,3H-QUINOLINE-2,5-DIONE(5057-12-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 5057-12-5(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

4,6,7,8-Tetrahydro-2,5(1H,3H)-quinolinedione (cas# 5057-12-5) is a compound useful in organic synthesis.

InChI:InChI=1/C9H11NO2/c11-8-3-1-2-7-6(8)4-5-9(12)10-7/h1-5H2,(H,10,12)

Upstream product

• 5220-49-5 3-amino-cyclohex-2-enone 
• 79-10-7 acrylic acid 
• 504-02-9 1,3-cylohexanedione 

Downstream Products

• 31570-97-5 5-hydroxyquinolin-2(1H)-one 
• 30389-33-4 5-hydroxycarbostyril 
• 16237-19-7 1-benzyl-4,6,7,8-tetrahydro-1H,3H-quinoline-2,5-dione 
• 125885-46-3 1-(4-Chlorobenzyl)-3,4,7,8-tetrahydro-2,5(1H_.6H)-quinolinedione 
• 98761-64-9 (4aα,5α,8aβ)-octahydro-1,5(2H)-quinolinedicarboxylic acid 1-phenylmethyl ester 
• 98761-60-5 (4aα,5β,8aβ)-octahydro-1,5(2H)-quinolinedicarboxylic acid 1-phenylmethyl ester 
• 98761-67-2 phenylmethyl (4aα,5α,8aβ)-5-(1,3-dithian-2-yl)octahydro-1(2H)-quinolinecarboxylate 
• 98761-69-4 phenylmethyl (4aα,5α,8aβ)-5-formyloctahydro-1(2H)-quinolinecarboxylate 
• 98761-71-8 phenylmethyl trans-octahydro-5-methylene-1(2H)quinolinecarboxylate 
• 98761-72-9 phenylmethyl (4aα,5β,8aβ)-octahydro-5-(hydroxymethyl)-1(2H)-quinolinecarboxylate 

Relevant articles and documents

Stable carteolol hydrochloride, preparation method thereof and eye medicine combination

The invention relates to stable carteolol hydrochloride, a preparation method thereof and an eye medicine combination, in particular to a method for preparing carteolol hydrochloride. The method comprises the following steps of preparing 3-amino-2-cyclohexenone, tetrahydro-2,5(1H, 6H)-quinolinone, 5-hydroxy-3,4-dihydro-2(1H)-carbostyril and 5-(2,3-epoxypropoxy)-3,4-dihydro-2(1H)-carbostyril, and then the carteolol hydrochloride is obtained. Furthermore, the invention provides the carteolol hydrochloride crude medicine obtained according to the method, the eye medicine combination prepared by using the obtained carteolol hydrochloride as the crude medicine, and applications of the obtained carteolol hydrochloride to preparation of drugs for treating or preventing glaucoma or ocular hypertension. The method has excellent pharmaceutical characteristics, for example, the obtained crude medicine and a preparation has excellent stability.

Pharmaceutical compositions containing quinolin-2,5-diones, new quinolin-2,5-diones and processes for the preparation thereof

This invention relates to pharmaceutical compositions containing quinolin-2,5-diones of formula STR1 wherein A, B, R1 to R3 and X are defined hereinbelow, some of which are novel, which compounds have valuable pharmacological propert