5059-52-9

Basic information

• Product Name: 6-(Pyridin-3-yl)-nicotinic acid
• Synonyms: 6-(Pyridin-3-yl)-nicotinic acid
• CAS NO: 5059-52-9
• Molecular Formula: C₁₁H₈N₂O₂
• Molecular Weight: 200.19
• Mol File: 5059-52-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-(Pyridin-3-yl)-nicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(Pyridin-3-yl)-nicotinic acid(5059-52-9)
• EPA Substance Registry System: 6-(Pyridin-3-yl)-nicotinic acid(5059-52-9)

Safety Data

• Hazardous Substances Data: 5059-52-9(Hazardous Substances Data)

Usage

General Description

6-(Pyridin-3-yl)-nicotinic acid, also known as 3-pyridyl-nicotinic acid, is a chemical compound with a molecular formula C11H8N2O2. It is a derivative of nicotinic acid, also known as niacin or vitamin B3, and contains a pyridine ring attached to a nicotinic acid moiety. 6-(Pyridin-3-yl)-nicotinic acid is used in the field of medicinal chemistry for its potential therapeutic applications, particularly in the development of novel drugs targeting the nicotinic acetylcholine receptors in the central nervous system. Additionally, its properties and potential pharmacological activities make it a valuable compound for further research in the areas of neuroscience and psychiatric disorders.

Upstream product

• 59-67-6 nicotinic acid 

Relevant articles and documents

Photochemistry of the three carboxypyridines in water: A pH dependent reaction

The photochemistry of ortho, meta and para-carboxypyridines (pK a1 = 1.0-2.1 and pKa1 = 4.7-5.3) in aqueous medium was studied by laser-flash photolysis and product studies. At pH a1, hydroxylated compounds are produced with low quantum yields. Within the pH range 4-7, ortho and meta isomers undergo dimerization together with decarboxylation with a quantum yield showing a very sharp maximum around pKa2 (φmax = 0.09 and 0.01, respectively) while the para isomer is photostable. End-of-pulse transients assigned to triplet states were detected by laser-flash photolysis at pH a1 and pH > 4. Additionally, the carboxypyridinyl radicals were detected as secondary intermediates at pH a1 and 4 a1. This is in favour of an electron transfer reaction between triplet and starting compound producing a charge transfer species. The radical anion would escape as carboxypyridinyl radical while the radical cation may add water at pH a1 yielding the OH-adduct radical or may undergo decarboxylation at pH > 4. The high quantum yield of phototransformation of the ortho isomer at pH > 4 is due to an easy decarboxylation process. A reaction scheme is proposed accounting for the dependences of φ on both the pH and the carboxypyridines concentration. This study points out the distinct pattern of reactivity of carboxypyridines depending on the ionisation state of starting compounds and isomeric substitution.