506-89-8

Basic information

• Product Name: UREA
• Synonyms: UREA, PRILLED;UREA HYDROCHLORIDE;UREA FERTILIZER;UREUM;AKOS BBS-00004448;CARBONYLDIAMIDE;CARBIMIDE;HARNSTOFF
• CAS NO: 506-89-8
• Molecular Formula: CH₅N₂O*Cl
• Molecular Weight: 60.06
• EINECS: 200-315-5
• Mol File: 506-89-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 132-135 °C(lit.)
• Boiling Point: 196.6 °C at 760 mmHg
• Flash Point: 72.7 °C
• Appearance: white/powder
• Density: 1.335 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.40
• Storage Temp.: 2-8°C
• Solubility: H2O: 8 M at 20 °C
• CAS DataBase Reference: UREA(CAS DataBase Reference)
• NIST Chemistry Reference: UREA(506-89-8)
• EPA Substance Registry System: UREA(506-89-8)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-40
• Safety Statements: 26-36
• WGK Germany: 1
• RTECS: YR6250000
• Hazardous Substances Data: 506-89-8(Hazardous Substances Data)

Usage

Chemical Description

Different sources of media describe the Chemical Description of 506-89-8 differently. You can refer to the following data:
1. Urea is an organic compound with the chemical formula CO(NH2)2, and N,N'-disubstituted ureas are urea derivatives with two substituents on the nitrogen atoms.
2. Urea is a common organic compound used in the production of fertilizers and plastics.
3. Urea and thiourea are organic compounds containing a carbonyl group and either a nitrogen or sulfur atom, respectively.
4. Urea is a compound used in fertilizers and various industrial processes.
5. Urea is a compound that is commonly used as a fertilizer and a raw material in the production of plastics and resins.
6. Urea is an organic compound with the chemical formula CO(NH2)2, and metal glycerolates are metal salts of glycerol.
7. Urea is an organic compound used in fertilizers and as a protein denaturant.
8. Urea is a white crystalline solid organic compound that is highly soluble in water.
9. Urea is a compound with the chemical formula CO(NH2)2, and maleic acid is a dicarboxylic acid with the chemical formula HO2CCH=CHCO2H.

Uses

Urea hydrochloride is nitrogen-release fertilizer. It is starting material for resins and plastics. Condensed with malonic ester to form barbituric acid. Used in the manufacture of paper.

InChI:InChI=1/CH4N2O.ClH/c2-1(3)4;/h(H4,2,3,4);1H/p-1

Synthetic route

urea (57-13-6) → urea hydrochloride (506-89-8)

Conditions	Yield
With sodium hypochlorite solution In water at 10℃; for 1h;	98.4%
With hydrogenchloride
With hydrogenchloride In water at 0 - 60℃; for 3h;

urea hydrochloride (506-89-8) → urea hydrobromide (94030-93-0)

Conditions	Yield
With hydrogenchloride; dihydrogen peroxide; sodium bromide In water for 1.5h;	98.7%

5-((5-chloro-4-methyl-1-phenyl-1H-pyrazol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione + urea hydrochloride (506-89-8) → 5-(5-chloro-4-methyl-1-phenyl-1H-pyrazol-3-yl)pyrimido[4,5-d]pyrimidine-2,4,7(1H,3H,4aH)-trione

Conditions	Yield
With acetic acid for 5h; Reflux;	74%

ethanol (64-17-5) + urea hydrochloride (506-89-8) → ammonium chloride

urea hydrochloride (506-89-8) → ammonium chloride + isocyanuric acid (108-80-5)

Conditions	Yield
at 145℃;

dibenzoazepine (256-96-2) + urea hydrochloride (506-89-8) → carbamazepin (298-46-4)

Conditions	Yield
In acetic acid
In acetic acid

urea hydrochloride (506-89-8) → cyanuric acid (108-80-5)

Conditions	Yield
heating;
heating;

calcium hypochlorite (7778-54-3) + urea hydrochloride (506-89-8) → N,N'-dichloro-urea (2959-01-5)

Conditions	Yield
In water 35°C;
In water 35°C;

urea hydrochloride (506-89-8) + mercury dichloride + mercury(II) oxide → 2Hg(2+)*NCONH2(2-)*2Cl(1-)=Hg2(NCONH2)Cl2 + water (7732-18-5)

urea hydrochloride (506-89-8) → cyanuric acid (108-80-5) + BIURET (108-19-0) + triuret (556-99-0) + ammonium chloride

Conditions	Yield
decompn. on heating at 150 - 154°C;

urea hydrochloride (506-89-8) + chlorine (7782-50-5) → chlorourea (3135-74-8)

Conditions	Yield
In water calculated amt. of Cl2, 20-35°C;
In water calculated amt. of Cl2, 20-35°C;

urea hydrochloride (506-89-8) + chlorine (7782-50-5) → N,N'-dichloro-urea (2959-01-5)

Conditions	Yield
In water calculated amt. of Cl2, 20-35°C;
In water calculated amt. of Cl2, 20-35°C;

urea hydrochloride (506-89-8) + chlorine (7782-50-5) → N,N-dichlorourea (36942-09-3)

Conditions	Yield
In water calculated amt. of Cl2, 20-35°C; N,-N'-dichlorourea extracted with CHCl3;
In water calculated amt. of Cl2, 20-35°C; N,-N'-dichlorourea extracted with CHCl3;

urea hydrochloride (506-89-8) + chlorine (7782-50-5) → tetrachlorourea (67700-36-1)

Conditions	Yield
In water calculated amt. of Cl2, 30°C; careful evapn.;
In water calculated amt. of Cl2, 30°C; careful evapn.;

2-phenyl-4'-(methylthio)acetophenone (73242-07-6) + urea hydrochloride (506-89-8) + 4-methyl-benzaldehyde (104-87-0) → C24H22N2OS (1393739-27-9)

Conditions	Yield
With potassium carbonate In ethanol Biginelli reaction; Reflux;

2-phenyl-4'-(methylthio)acetophenone (73242-07-6) + urea hydrochloride (506-89-8) + 4-chlorobenzaldehyde (104-88-1) → C23H19ClN2OS (1393739-29-1)

Conditions	Yield
With potassium carbonate In ethanol Biginelli reaction; Reflux;

2-phenyl-4'-(methylthio)acetophenone (73242-07-6) + urea hydrochloride (506-89-8) + 3-nitro-benzaldehyde (99-61-6) → C23H19N3O3S (1393739-32-6)

Conditions	Yield
With potassium carbonate In ethanol Biginelli reaction; Reflux;

2-phenyl-4'-(methylthio)acetophenone (73242-07-6) + urea hydrochloride (506-89-8) + benzaldehyde (100-52-7) → C23H20N2OS (1393739-26-8)

Conditions	Yield
With potassium carbonate In ethanol Biginelli reaction; Reflux;

2-phenyl-4'-(methylthio)acetophenone (73242-07-6) + urea hydrochloride (506-89-8) + 4-hydroxy-benzaldehyde (123-08-0) → C23H20N2O2S (1393739-28-0)

Conditions	Yield
With potassium carbonate In ethanol Biginelli reaction; Reflux;

2-phenyl-4'-(methylthio)acetophenone (73242-07-6) + urea hydrochloride (506-89-8) + 4-methoxy-benzaldehyde (123-11-5) → C24H22N2O2S (1393739-30-4)

Conditions	Yield
With potassium carbonate In ethanol Biginelli reaction; Reflux;

2-phenyl-4'-(methylthio)acetophenone (73242-07-6) + urea hydrochloride (506-89-8) + 3,4-dimethoxy-benzaldehyde (120-14-9) → C25H24N2O3S (1393739-34-8)

Conditions	Yield
With potassium carbonate In ethanol Biginelli reaction; Reflux;

2-phenyl-4'-(methylthio)acetophenone (73242-07-6) + urea hydrochloride (506-89-8) + 4-dimethylamino-benzaldehyde (100-10-7) → C25H25N3OS (1393739-33-7)

Conditions	Yield
With potassium carbonate In ethanol Biginelli reaction; Reflux;

2-phenyl-4'-(methylthio)acetophenone (73242-07-6) + urea hydrochloride (506-89-8) + 2,4-Dimethoxybenzaldehyde (613-45-6) → C25H24N2O3S (1393739-35-9)

Conditions	Yield
With potassium carbonate In ethanol Biginelli reaction; Reflux;

2-phenyl-4'-(methylthio)acetophenone (73242-07-6) + urea hydrochloride (506-89-8) + 2-nitro-benzaldehyde (552-89-6) → C23H19N3O3S (1393739-31-5)

Conditions	Yield
With potassium carbonate In ethanol Biginelli reaction; Reflux;

urea hydrochloride (506-89-8) + ethylenediamine (107-15-3) → C2H8N2*CH4N2O*ClH

Conditions	Yield
for 0.5h;

Upstream product

• 57-13-6 urea 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 1393739-31-5 C₂₃H₁₉N₃O₃S 
• 1393739-35-9 C₂₅H₂₄N₂O₃S 
• 1393739-33-7 C₂₅H₂₅N₃OS 
• 1393739-34-8 C₂₅H₂₄N₂O₃S 
• 1393739-30-4 C₂₄H₂₂N₂O₂S 
• 1393739-28-0 C₂₃H₂₀N₂O₂S 
• 1393739-26-8 C₂₃H₂₀N₂OS 
• 1393739-32-6 C₂₃H₁₉N₃O₃S 
• 1393739-29-1 C₂₃H₁₉ClN₂OS 
• 1393739-27-9 C₂₄H₂₂N₂OS 
• 108-80-5 cyanuric acid 
• 108-19-0 BIURET 
• 556-99-0 triuret 
• 298-46-4 carbamazepin 

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