5060-52-6

Basic information

• Product Name: 2-Methyl-3-(2-methyl-4-hydroxyphenyl)quinazoline-4(3H)-one
• Synonyms: 2-Methyl-3-(2-methyl-4-hydroxyphenyl)quinazoline-4(3H)-one;3-(4-Hydroxy-2-methylphenyl)-2-methylquinazolin-4(3H)-one;4'-Hydroxymethaqualone
• CAS NO: 5060-52-6
• Molecular Formula: C₁₆H₁₄N₂O₂
• Molecular Weight: 266.2946
• Mol File: 5060-52-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 481.1°Cat760mmHg
• Flash Point: 244.8°C
• Appearance: /
• Density: 1.25g/cm³
• Vapor Pressure: 6.99E-10mmHg at 25°C
• Refractive Index: 1.642
• CAS DataBase Reference: 2-Methyl-3-(2-methyl-4-hydroxyphenyl)quinazoline-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-3-(2-methyl-4-hydroxyphenyl)quinazoline-4(3H)-one(5060-52-6)
• EPA Substance Registry System: 2-Methyl-3-(2-methyl-4-hydroxyphenyl)quinazoline-4(3H)-one(5060-52-6)

Safety Data

• Hazardous Substances Data: 5060-52-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H14N2O2/c1-10-9-12(19)7-8-15(10)18-11(2)17-14-6-4-3-5-13(14)16(18)20/h3-9,19H,1-2H3

Upstream product

• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 2835-99-6 4-amino-3-methylphenol 

Downstream Products

• 1137896-40-2 C₂₃H₁₈N₂O₂ 
• 1137896-37-7 C₂₃H₁₉N₃O₃ 
• 1137896-49-1 ethyl 2-[3-methyl-4-(2-methyl-4-oxo-3,4-dihydro-3-quinazolinyl)phenoxy]acetate 
• 1137896-36-6 C₂₃H₂₅N₃O₃ 
• 1137896-41-3 C₂₅H₂₀N₂O₂ 
• 1137896-31-1 C₂₃H₂₀N₂O₂ 
• 1137896-30-0 C₁₈H₁₈N₂O₂ 
• 50868-81-0 3-(4-methoxy-2-methyl-phenyl)-2-methyl-3H-quinazolin-4-one 

Relevant articles and documents

Synthesis of some substituted 4(3H) quinazolinones of diverse biological activities

THE SYNTHESIS of 3-(3-hydroxy-4-methoxyphenyl) and 3-(4-hydroxy-2- methylphenyl)-4(3H)-quinazolinone and their nitroanalogs 2 and 3 is described. Reaction of 2 and 3 with alkyl halides gave the alkoxy derivatives 4 and 7 , reaction with alkyl or aryl isocyanates afforded the alkyl or aryl carbamoyloxy derivatives 5 and 8 , while reaction with aldehydes yielded the 2-styryl derivatives 6 and 9. Refluxing 3 with secondary amines and formaldehyde produced mannich bases 10. Reaction of 3 with ethyl chloroacetate gave the ethyl phenoxyacetate 11 which upon refluxing with hydrazine hydrate yielded the acid hydrazide 12. Further reaction of 12 with aldehydes or isothiocyanates afforded the hydrazones 13 or the thiosemicarbazides 14, respectively. Cyclization of the latter with chloroacetic acid produced the thiazolidinones 15. Fifteen of the newly synthesized compounds were screened for tranquillizing , anticonvulsant and analgesic activities. Twelve of the tested compounds showed marked activities.