5060-56-0

Basic information

• Product Name: 2-Chloro-10-[2-(1-methyl-2-piperidyl)ethyl]-10H-phenothiazine
• Synonyms: 2-Chloro-10-[2-(1-methyl-2-piperidinyl)ethyl]-10H-phenothiazine;2-Chloro-10-[2-(1-methyl-2-piperidyl)ethyl]-10H-phenothiazine;NP-207;Piperidochlorpromazine
• CAS NO: 5060-56-0
• Molecular Formula: C20H23ClN2S
• Molecular Weight: 358.93
• Mol File: 5060-56-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 492.5°C at 760 mmHg
• Flash Point: 251.7°C
• Appearance: /
• Density: 1.197g/cm³
• Vapor Pressure: 7.63E-10mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 2-Chloro-10-[2-(1-methyl-2-piperidyl)ethyl]-10H-phenothiazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-10-[2-(1-methyl-2-piperidyl)ethyl]-10H-phenothiazine(5060-56-0)
• EPA Substance Registry System: 2-Chloro-10-[2-(1-methyl-2-piperidyl)ethyl]-10H-phenothiazine(5060-56-0)

Safety Data

• Hazardous Substances Data: 5060-56-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H23ClN2S/c1-22-12-5-4-6-16(22)11-13-23-17-7-2-3-8-19(17)24-20-10-9-15(21)14-18(20)23/h2-3,7-10,14,16H,4-6,11-13H2,1H3

Upstream product

• 92-39-7 2-chlorophenothiazine 
• 118811-03-3 tert-butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate 
• 1484-84-0 2(RS)-(2-hydroxyethyl)piperidine 
• 50-00-0 formaldehyd 
• 102176-92-1 2-chloro-10-(2-(piperidin-2-yl)ethyl)-10H-phenothiazine 
• 210564-52-6 t-butyl 2-(2-bromoethyl)piperidine-1-carboxylate 

Relevant articles and documents

Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis

The neuroleptic drug thioridazine has been recently repositioned as possible anti-tubercular drug. Thioridazine showed anti-tubercular activity against drug resistant mycobacteria but it is endowed with adverse side effects. A small library of thioridazine derivatives has been designed through the replacement of the piperidine and phenothiazine moieties, with the aim to improve the anti-tubercular activity and to reduce the cytotoxic effects. Among the resulting compounds, the indole derivative 12e showed an antimycobacterial activity significantly better than thioridazine and a cytotoxicity 15-fold lower.