50629-82-8

Basic information

• Product Name: Halometasone
• Synonyms: HALOMETASONE;HALOMETASONE HYDRATE;HALOMETASONE MONOHYDRATE;2-chlor-6a,9-difluor-11b,17,21-trihydroxy-16a-methyl-1,4-pregnadien-3,20-dion;2-chloroflumethasone;(6α，11β，16α)-2-Chloro-6，9-difluoro-11，17，21-trihydroxy-16-methylpregna-1，4-diene-3，20-dione;Halomethasone;Sicorten
• CAS NO: 50629-82-8
• Molecular Formula: C₂₂H₂₇ClF₂O₅
• Molecular Weight: 444.9
• EINECS: 256-664-9
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 50629-82-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 220-222° (dec)
• Boiling Point: 600.538 °C at 760 mmHg
• Flash Point: 316.994 °C
• Appearance: /
• Density: 1.422 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: Refrigerator
• Solubility: Acetone (Sparingly), DMSO (Slightly), Methanol (Slightly)
• PKA: 11.93±0.70(Predicted)
• CAS DataBase Reference: Halometasone(CAS DataBase Reference)
• NIST Chemistry Reference: Halometasone(50629-82-8)
• EPA Substance Registry System: Halometasone(50629-82-8)

Safety Data

• Hazardous Substances Data: 50629-82-8(Hazardous Substances Data)

Usage

Description

Halometasone is a Dotent, topical steroid useful in a variety of acute and chronic eczematous dermaioses and psoriasis. It is reportedly devoid of skin toxicity and systemic effects.

Originator

Ciba-Geigy (Switzerland)

Uses

A corticosteroid used in the treatment of skin disorders such as chronic eczema.

Brand name

SICORTEN

InChI:InChI=1/C22H27ClF2O5/c1-10-4-11-12-5-15(24)13-6-16(27)14(23)7-19(13,2)21(12,25)17(28)8-20(11,3)22(10,30)18(29)9-26/h6-7,10-12,15,17,26,28,30H,4-5,8-9H2,1-3H3/t10-,11+,12+,15+,17+,19+,20+,21+,22+/m1/s1

Relevant articles and documents

Synthesis method and application of 9-fluorosteroid compound

The invention provides a synthesis method and application of a 9-fluorosteroid compound, and relates to the technical field of chemical synthesis. The synthesis method of the 9-fluorosteroid compoundcomprises the following step: reacting a compound II in an ionic liquid containing hydrogen fluoride salt to obtain a 9-fluorosteroid compound III. According to the synthesis method of the 9-fluorosteroid compound, the ionic liquid containing the hydrogen fluoride salt is used as a fluorinating agent to replace a traditional hydrogen fluoride aqueous solution, volatilization of hydrogen fluoride gas is avoided, corrosivity is small, toxicity is greatly reduced, reaction conditions are mild, reaction can be completed at the room temperature, operability is high, the safety coefficient is high,and production applicability is improved. The synthesis method of the 9-fluorosteroid compound is used for preparing corticosteroid drugs, highly toxic chemical reagents are not used in the synthesisroute, the operability is high, the safety coefficient is high, and the production applicability is improved.