50638-51-2

Basic information

• Product Name: 4-BROMO-2-CHLORO-N,N-DIMETHYLANILINE
• Synonyms: 4-BROMO-2-CHLORO-N,N-DIMETHYLANILINE
• CAS NO: 50638-51-2
• Molecular Formula: C₈H₉BrClN
• Molecular Weight: 234.52
• Mol File: 50638-51-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 270.328 °C at 760 mmHg
• Flash Point: 117.29 °C
• Appearance: /
• Density: 1.508 g/cm³
• CAS DataBase Reference: 4-BROMO-2-CHLORO-N,N-DIMETHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-CHLORO-N,N-DIMETHYLANILINE(50638-51-2)
• EPA Substance Registry System: 4-BROMO-2-CHLORO-N,N-DIMETHYLANILINE(50638-51-2)

Safety Data

• Hazardous Substances Data: 50638-51-2(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-chloro-N,N-dimethylaniline is a chemical compound with the molecular formula C8H10BrClN. It is a derivative of aniline with a bromine and chlorine substitution on the 4th and 2nd positions, respectively, and two methyl groups attached to the amine nitrogen. 4-BROMO-2-CHLORO-N,N-DIMETHYLANILINE is widely used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is also used as a reagent in organic synthesis and as a precursor for the production of other important chemical compounds. 4-Bromo-2-chloro-N,N-dimethylaniline is a toxic and harmful chemical and should be handled with care in a controlled laboratory environment.

Upstream product

• 586-77-6 4-bromo-N,N-dimethylaniline 
• 38762-41-3 2-chloro-4-bromoaniline 
• 74-88-4 methyl iodide 

Downstream Products

• 50638-47-6 4-bromo-2-chloro-1-methoxybenzene 

Relevant articles and documents

In situ Generation of Hypervalent Iodine Reagents for the Electrophilic Chlorination of Arenes

Efficient metal-free methods for the electrophilic chlorination of arenes using PIFA and simple chlorine sources are reported. The in situ formation of PhI(Cl)OCOCF3 from PIFA and KCl is proposed, which resulted in a chlorinating species for moderately activated arenes. Moreover, the in situ formation of PhICl2 from PIFA and TMSCl resulted in an excellent approach for the chlorination of a great variety of arenes (20 examples) in high yields, even when working on a multigram scale.

The Chlorination of Some N,N-Dimethylanilines with 1,3,5-Trichloro-1,3,5-triazine-2,4,6-(1H,3H,5H)-trione (Trichloroisocyanuric Acid)

The reaction of some representative N,N-dimethylanilines and of Fischer's base (1,3,3-trimethyl-2-methyleneindoline) with trichloroisocyanuric acid in concetrated sulfuric acid has been investigated.In many cases mixtures of chlorinated products were obtained; these mixtures were examined both by gas-liquid chromatography and by proton magnetic resonance spectroscopy.The reaction of N,N-dimethylaniline with dichloroisocyanuric acid was also studied.A feature of these chlorinations is the marked tendency for substitution to occur ortho to the dimethylamino group.This behaviour therefore differs from that reported for the corresponding brominations involving dibromoisocyanuric acid, where meta-substitution was observed.