5064-00-6

Basic information

• Product Name: 3-(4-METHOXYBENZOYL)THIOPHENE
• Synonyms: 3-(4-METHOXYBENZOYL)THIOPHENE;5-amino-2,3-dihydrophthalazine-1,4-quinone;5-azanyl-2,3-dihydrophthalazine-1,4-dione
• CAS NO: 5064-00-6
• Molecular Formula: C₁₂H₁₀O₂S
• Molecular Weight: 218.27
• Mol File: 5064-00-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 353.291°C at 760 mmHg
• Flash Point: 167.465°C
• Appearance: /
• Density: 1.206g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: 3-(4-METHOXYBENZOYL)THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-METHOXYBENZOYL)THIOPHENE(5064-00-6)
• EPA Substance Registry System: 3-(4-METHOXYBENZOYL)THIOPHENE(5064-00-6)

Safety Data

• Hazardous Substances Data: 5064-00-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H10O2S/c1-14-11-4-2-9(3-5-11)12(13)10-6-7-15-8-10/h2-8H,1H3

Upstream product

• 6165-69-1 Thien-3-ylboronic acid 
• 794-94-5 p-Methoxybenzoic anhydride 
• 436093-36-6 (2-aminothiophen-3-yl)(4-methoxyphenyl)methanone 
• 213596-33-9 2-(4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborolane 
• 872-31-1 3-Bromothiophene 
• 109-72-8 n-butyllithium 
• 874-90-8 4-methoxybenzonitrile 

Downstream Products

• 118976-96-8 4-(4-methoxybenzoyl)thiophene-2-sulfonic acid 
• 143509-85-7 4-<3-<(N-isobutyl-N-methylamino)methyl>-4-hydroxybenzoyl>thiophene-2-sulfonamide 
• 143509-84-6 4-<3-<(diethylamino)methyl>-4-hydroxybenzoyl>thiophene-2-sulfonamide 
• 118993-60-5 4-<3-<(dimethylamino)methyl>-4-hydroxybenzoyl>thiophene-2-sulfonamide 
• 118976-97-9 4-(4-Methoxybenzoyl)thiophene-2-sulfonamide 
• 143509-75-5 4-(4-Methoxy-benzoyl)-thiophene-2-sulfonyl chloride 
• 118993-57-0 4-(4-hydroxybenzoyl)thiophene-2-sulfonamide 

Relevant articles and documents

Flow hydrodediazoniation of aromatic heterocycles

Continuous flow processing was applied for the rapid replacement of an aromatic amino group with a hydride. The approach was applied to a range of aromatic heterocycles, confirming the wide scope and substituent-tolerance of the processes. Flow equipment was utilized and the process optimised to overcome the problematically-unstable intermediates that have restricted yields in previous studies relying on batch procedures. Various common organic solvents were investigated as potential hydride sources. The approach has allowed key structures, such as amino-pyrazoles and aminopyridines, to be deaminated in good yield using a purely organic-soluble system.

Ni-Catalyzed cross-coupling reactions of N-acylpyrrole-type amides with organoboron reagents

The catalytic conversion of amides to ketones is highly desirable yet challenging in organic synthesis. We herein report the first Ni/bis-NHC-catalyzed cross-coupling of N-acylpyrrole-type amides with arylboronic esters to obtain diarylketones. This method is facilitated by a new chelating bis-NHC ligand. The reaction tolerates diverse functional groups on both arylamide and arylboronic ester partners including sensitive ester and ketone groups.

3-(diheteroarylmethylene)-8-azabicyclo[3.2.1]octane and 3-((aryl)(heteroaryl)methylene)-8-azabicyclo[3.2.1]octane derivatives

This invention is directed to 3-(diheteroarylmethylene)-8-azabicyclo[3.2.1] octane and 3-((aryl)(heteroaryl)methylene)-8-azabicyclo[3.2.1] octane derivatives useful as δ-opioid, μ-opioid, or δ-opioid and μ-opioid receptor receptor modulators. Depending on