50700-60-2

Basic information

• Product Name: 4(1H)-Pyridinone,3-methoxy-(9CI)
• Synonyms: 4(1H)-Pyridinone,3-methoxy-(9CI)
• CAS NO: 50700-60-2
• Molecular Formula: C6H7NO2
• Molecular Weight: 125.12528
• Product Categories: PYRIDINE
• Mol File: 50700-60-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 251.2°C at 760 mmHg
• Flash Point: 105.7°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 0.0207mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: 4(1H)-Pyridinone,3-methoxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyridinone,3-methoxy-(9CI)(50700-60-2)
• EPA Substance Registry System: 4(1H)-Pyridinone,3-methoxy-(9CI)(50700-60-2)

Safety Data

• Hazardous Substances Data: 50700-60-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H7NO2/c1-9-6-4-7-3-2-5(6)8/h2-4H,1H3,(H,7,8)

Upstream product

• 1193-64-2 3-methoxy-4H-pyran-4-one 
• 1199-60-6 5-methoxy-4-oxo-4H-pyran-2-carboxylic acid 
• 6269-25-6 2-Hydroxymethyl-5-methoxy-4H-pyran-4-on 
• 501-30-4 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one 

Downstream Products

• 2116-55-4 mimosine 

Relevant articles and documents

Systematic comparison of the mono-, dimethyl-and trimethyl 3-hydroxy-4(1H)-pyridones-Attempted optimization of the orally active iron chelator, deferiprone

A range of close analogues of deferiprone have been synthesised. The group includes mono-, di-and trimethyl-3-hydroxy-4(1H)-pyridones. These compounds were found to possess similar pFe3+ values to that of deferiprone, with the exception of the 2.5-dimethylated derivatives. Surprisingly the NHcontaining hydroxy-4(1H)-pyridones were found to be marginally more lipophilic than the corresponding N-Me containing analogues. This same group are also metabolised less efficiently by Phase 1 hydroxylating enzymes than the corresponding N-Me analogues. As result of this study, three compounds have been identified for further investigation centred on neutropenia and agranulocytosis.