50741-92-9

Basic information

• Product Name: 2-METHYL-4-NITROANISOLE 97
• Synonyms: 2-METHYL-4-NITROANISOLE 97;2-METHYL-4-NITROANISOLE 97%;3-Methyl-4-Methoxynitrobenzene;4-Methoxy-3-Methylnitrobenzene;Benzene, 1-Methoxy-2-Methyl-4-nitro-
• CAS NO: 50741-92-9
• Molecular Formula: C8H9NO3
• Molecular Weight: 167.16
• EINECS: 256-748-5
• Product Categories: Aromatics Compounds;Aromatics;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
• Mol File: 50741-92-9.mol
• Article Data: 17

Chemical Properties

• Melting Point: 61-64 °C(lit.)
• Boiling Point: 283 °C at 760 mmHg
• Flash Point: 136.7 °C
• Appearance: Off-white solid
• Density: 1.18 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-METHYL-4-NITROANISOLE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-4-NITROANISOLE 97(50741-92-9)
• EPA Substance Registry System: 2-METHYL-4-NITROANISOLE 97(50741-92-9)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 50741-92-9(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

2-Methyl-4-nitroanisole may be used in the synthesis of 2-methyl-4-nitrophenol and 3-methyl-4-methoxyaniline.

General Description

2-Methyl-4-nitroanisole is obtained as one of the products from the charge-transfer trinitromethylation of 2-methylanisole in the presence of dichloromethane.

Upstream product

• 13290-74-9 1-chloro-2-methyl-4-nitrobenzene 
• 124-41-4 sodium methylate 
• 509-14-8 tetranitromethane 
• 578-58-5 2-methylmethoxybenzene 
• 3913-23-3 2-methoxy-5-nitrobenzyl bromide 
• 67-56-1 methanol 
• 455-88-9 5-nitro-2-fluorotoluene 
• 143359-98-2 acetic acid-(2-methoxy-3-methyl-anilide) 
• 18102-30-2 2-methoxy-3-methylaniline 
• 6880-04-2 4-methoxy-3-methylbenzoic acid 
• 7697-37-2 nitric acid 
• 56-23-5 tetrachloromethane 
• 99-53-6 2-methyl-4-nitrophenol 
• 74-88-4 methyl iodide 

Downstream Products

• 29027-13-2 2-methyl-4,6-dinitroanisole 
• 136-90-3 4-methoxy-3-methylaniline 
• 99-53-6 2-methyl-4-nitrophenol 
• 328400-86-8 2-bromo-4-methoxy-5-methylaniline 
• 1354189-98-2 C₃₉H₃₇ClN₂O₅ 
• 1354189-97-1 (S)-(9H-fluoren-9-yl)methyl 2-(6-(1-tert-butoxy-2-hydroxyethyl)-5-(4-chlorophenyl)-7-methyl-2-oxoquinolin-1(2H)-yl)ethylcarbamate 
• 1354189-95-9 (S)-2-(trimethylsilyl)ethyl 2-(6-(1-tert-butoxy-2-(tert-butyldimethylsilyloxy)ethyl)-5-(4-chlorophenyl)-7-methyl-2-oxoquinolin-1(2H)-yl)ethylcarbamate 
• 1354189-92-6 (S)-6-(1-tert-butoxy-2-(tert-butyldimethylsilyloxy)ethyl)-5-(4-chlorophenyl)-7-methylquinolin-2(1H)-one 
• 1354186-28-9 (S)-2-(1-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-tert-butoxyacetic acid 
• 1354189-70-0 (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-7-methylquinolin-6-yl)ethanol 
• 1354189-68-6 (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-7-methylquinolin-6-yl)ethyl pivalate 
• 1354189-65-3 (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-isopropyl-7-methylquinolin-6-yl)ethanol 
• 1354189-62-0 (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-isopropyl-7-methylquinolin-6-yl)ethyl pivalate 
• 1354186-22-3 (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-7-methylquinolin-6-yl)acetic acid 

Relevant articles and documents

Eco-Friendly Methodology for the Formation of Aromatic Carbon–Heteroatom Bonds by Using Green Ionic Liquids

A new sustainable method is reported for the formation of aromatic carbon–heteroatom bonds under solvent-free and mild conditions (no co-oxidant, no strong acid and no toxic reagents) by using a new type of green ionic liquid. The bromination of methoxy arenes was chosen as a model reaction. The reaction methodology is based on only using natural sodium bromine, which is transformed into an electrophilic brominating reagent within an ionic liquid, easily prepared from the melted salt FeCl3 hexahydrate. Bromination reactions with this in-situ-generated reagent gave good yields and excellent regioselectivity under simple and environmentally friendly conditions. To understand the unusual bromine polarity reversal of sodium bromine without any strong oxidant, the molecular structure of the reaction medium was characterised by Raman and direct infusion electrospray ionisation mass spectroscopy (ESI-MS). An extensive computational investigation using density functional theory methods was performed to describe a mechanism that suggests indirect oxidation of Br? through new iron adducts. The versatility of the methodology was successively applied to nitration and thiocyanation of methoxy arenes using KNO3 and KSCN in melted hexahydrated FeCl3.

Triton B-mediated efficient and convenient alkoxylation of activated aryl and heteroaryl halides

A simple and convenient one-pot synthesis of aryl alkyl ethers by the alkoxylation of aryl halides with alcohol in the presence of Triton B as a base is described. The procedure is applicable for a variety of aryl and heteroaryl halides, and yields are very good. The use of a nonmetallic base and solvent-free conditions are important features of the reaction. Copyright Taylor & Francis Group, LLC.

Nitration of some aromatic compounds by sodium nitrate in the presence of benzyltriphenylphosphonium peroxodisulfate

A simple, mild, and regioselective method for the nitration of some aromatic compounds using sodium nitrate in the presence of benzyltriphenylphosphonium peroxodisulfate in acetonitrile as solvent is reported. Mild reaction conditions and good to excellent yields of the products are the noteworthy advantages of the method. Copyright Taylor & Francis Group, LLC.