50784-07-1

Basic information

• Product Name: N-ALLYLISATOIC ANHYDRIDE
• Synonyms: N-ALLYLISATOIC ANHYDRIDE;1-ALLYL-1,4-DIHYDRO-2H-3,1-BENZOXAZINE-2,4-DIONE;N-Allylisatoic anhydride 98%;1-prop-2-enyl-3,1-benzoxazine-2,4-dione
• CAS NO: 50784-07-1
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.19
• Mol File: 50784-07-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 104-106
• Boiling Point: 325.6 °C at 760 mmHg
• Flash Point: 150.7 °C
• Appearance: /
• Density: 1.265 g/cm³
• Vapor Pressure: 0.000228mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: N-ALLYLISATOIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ALLYLISATOIC ANHYDRIDE(50784-07-1)
• EPA Substance Registry System: N-ALLYLISATOIC ANHYDRIDE(50784-07-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 50784-07-1(Hazardous Substances Data)

Usage

General Description

N-ALLYLISATOIC ANHYDRIDE is a chemical compound with the molecular formula C8H10O3. It is an aromatic anhydride that is used in the synthesis of various pharmaceuticals and organic compounds. The compound is known for its reactivity and ability to undergo nucleophilic addition reactions. It is also used as a building block for the production of polymers and resin systems. N-ALLYLISATOIC ANHYDRIDE is classified as an irritant and should be handled with care to avoid skin and respiratory irritation.

InChI:InChI=1/C11H9NO3/c1-2-7-12-9-6-4-3-5-8(9)10(13)15-11(12)14/h2-6H,1,7H2

Upstream product

• 830-74-0 1-allyl-1H-indole-2,3-dione 
• 118-48-9 isatoic anhydride 
• 106-95-6 allyl bromide 
• 556-56-9 allyl iodid 

Downstream Products

• 1261594-07-3 1-allyl-3-benzyl-3,4-dihydro-1H-benzo[d][1,3]diazepine-5(2H)-one 
• 1408002-70-9 2-(allylamino)-N-isopropylbenzamide 
• 1408002-73-2 C₁₇H₁₇ClN₂O 
• 1408002-67-4 2-(allylamino)-N-benzylbenzamide 
• 1408002-72-1 C₁₇H₁₇ClN₂O 
• 1408002-71-0 C₁₃H₁₆N₂O 
• 1408002-69-6 C₁₆H₂₂N₂O 
• 1408002-68-5 C₁₈H₂₀N₂O 
• 1408002-76-5 C₁₄H₂₀N₂O 
• 1408002-75-4 C₁₇H₁₇FN₂O 
• 1408002-74-3 C₁₇H₁₇ClN₂O 
• 1411642-02-8 2,2,2-trifluoro-1-[2-(allylamino)phenyl]ethanone 
• 1407751-69-2 C₁₉H₂₄N₂O₂ 
• 1380589-77-4 C₁₄H₂₀N₂O 

Relevant articles and documents

Aza11-membered ring compound, preparation method and application thereof, and medicine containing aza11-membered ring compound

The invention discloses an aza 11-membered ring compound haveing the following structural general formula shown in the specification, and also provides a method for preparing the compound. The methodcomprises the following steps of: under the condition of argon, by taking methylbenzene as a solvent, coordinating a tri(dibenzylidene acetone)dipalladium-chloroform adduct with a (4,5-bis(diphenylphosphine)-9,9-dimethylxanthene)phosphine ligand; stirring, adding a substrate 1 and a substrate 2 after the solution turns yellow from red, and carrying out a reaction to obtain a final product 3 afterthe reaction is finished. The invention also discloses application of the compound and a medicine containing the compound. According to the invention, the exploration of the compound with the middle ring structure is further deeply carried out, the compound with the middle ring structure also has pharmaceutical activity, the preparation method capable of expanding production and large-scale production is provided, the adopted reaction substrate raw materials are very easy to obtain, the reaction conditions of the preparation method are easy to realize, the reaction time is shortened to the maximum extent, and high yield can be obtained.

Synthesis, anti-varicella-zoster virus and anti-cytomegalovirus activity of quinazoline-2,4-diones containing isoxazolidine and phosphonate substructures

Cycloadditions of N-substituted C-(diethoxyphosphoryl)nitrones to N-allylated quinazoline-2,4-diones functionalized at N3 with substituted benzoyl or benzyl groups proceeded with moderate to good diastereoselectivities (d.e. 28–68%). The synthesized isoxazolidine phosphonates were assessed for the antiviral activity against a broad range of DNA and RNA viruses. Compounds trans-13c, cis-13c/trans-13c (86:14), cis-15b/trans-15b (87:13) and trans-15d/cis-15d (95:5) exhibited the highest activity toward both TK+and TK?VZV strains (mean EC50values in the range of 3.0–8.7?μM). The EC50's for isoxazolidines trans-12a, cis-12a, cis-13a, trans-13d, cis-15a/trans-15a (50:50) ranged between 6.9 and 8.5?μM for VZV TK+strain and between 10.7 and 13.2?μM for VZV TK–strain. The isoxazolidine phosphonates cis-15/trans-15 having benzyl substituents both at N3 of the quinazoline-2,4-dione skeleton and at N2 of the isoxazolidine ring displayed some anti-cytomegalovirus potency but at the same time showed significant cytostatic activity for human embryonic lung fibroblasts (used to carry out the antiviral assays) as well as for other cell lines (i.e. CEM, L1210, HeLa and HMEC-1).

PYRIMIDO [4,5-B]QUINOLINE-4,5 (3H,10H)-DIONES AS NONSENSE MUTATION SUPPRESSORS

The invention relates to compound of the formula (I); or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.