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508-54-3 Usage

Uses

An intermediate in the preparation of Oxycodone and other alkaloid based opiate antagonists.

Check Digit Verification of cas no

The CAS Registry Mumber 508-54-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 8 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 508-54:
(5*5)+(4*0)+(3*8)+(2*5)+(1*4)=63
63 % 10 = 3
So 508-54-3 is a valid CAS Registry Number.

508-54-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name	14-Hydroxy Codeinone

1.2 Other means of identification

Product number	-
Other names	Morpholine,4-(9bb-ethyl-1,2,3,3ab,8,9,9ab,9b-octahydro-5-methoxyphenanthro[4,5-bcd]furan-3-yl)-(8CI)

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:508-54-3 SDS

508-54-3Upstream product

508-54-3Downstream Products

508-54-3Relevant articles and documents

A simple and practical method for the oxidation of thebaine to 14-hydroxycodeinone by V2O5-H2O2

Sharma, Saikat Das,Konwar, Dilip

, p. 1062 - 1064 (2009)

An efficient, practical and expeditious method has been developed for the oxidation of thebaine to 14-hydroxycodeinone in excellent yield by employing 20 mol% of V2O5 in the presence of 30% H2O 2 in aqueous medium. The method provides a clean technological process for the preparation of a key drug intermediate, 14-hydroxycodeinone. Georg Thieme Verlag Stuttgart.

Groeger,Schmauder

, p. 95 (1969)

Studies on morphine-like compounds. VI. Transformation of thebaine to benzomorphan analogues by ozonolysis.

Sasaki,Kanematsu

, p. 1247 - 1250 (1967)

Studies into the direct oxidation of codeinone to 14-hydroxycodeinone

Coop, Andrew,Rice, Kenner C.

, p. 11429 - 11436 (1999)

The direct oxidation of codeinone (5) to 14-hydroxycodeinone (6) was investigated with a wide range of oxidizing agents. The majority of reagents gave little or no desired product. Peracids were found to be moderately successful, with dimethyl peracetic acid giving the greatest yield (37%). Metallic oxidants generally gave rise to competing oxidations, however Co(AcO)3 was found to conveniently oxidize 5 to 6 in 51% yield, representing a practical, non-chromatographic procedure for the preparation of 14- hydroxycodeinone.

-

Hauser et al.

, p. 1117 (1974)

PROCESSES FOR PREPARING NOR-OPIOID COMPOUNDS AND OPIOID ANTAGONISTS BY ELECTROCHEMICAL N-DEMETHYLATION

-

Page/Page column 26, (2021/12/31)

The present invention relates to a process for preparing a nor-opioid compound wherein an opioid precursor compound is electrochemically N-demethylated. The present invention further relates to a process for preparing an opioid antagonist compound, wherein an opioid precursor compound is electrochemically N-demethylated and the thus obtained nor-opioid compound is alkylated again at its secondary amine functional group.

PROCESS FOR IMPROVED OXYCODONE SYNTHESIS

-

Paragraph 0615-0638, (2017/02/24)

Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.

CAS

508-54-3