508203-26-7

Basic information

• Product Name: 4-chloro-2,5-difluorobenzamide
• Synonyms: 4-chloro-2,5-difluorobenzamide
• CAS NO: 508203-26-7
• Molecular Formula: C₇H₄ClF₂NO
• Molecular Weight: 191.56
• Mol File: 508203-26-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-chloro-2,5-difluorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2,5-difluorobenzamide(508203-26-7)
• EPA Substance Registry System: 4-chloro-2,5-difluorobenzamide(508203-26-7)

Safety Data

• Hazardous Substances Data: 508203-26-7(Hazardous Substances Data)

Upstream product

• 132794-07-1 4-chloro-2,5-difluoro-benzoic acid 
• 132794-08-2 2,5-difluoro-4-chlorobenzoyl chloride 

Downstream Products

• 764648-58-0 4-chloro-2-(4-chloro-2,5-difluorophenyl)-6-methylpyrimidine 
• 764648-59-1 4-chloro-2-(4-chloro-2,5-difluorophenyl)-6-ethylpyrimidine 
• 1395553-38-4 C₂H₂O₄*C₁₈H₁₅ClF₂N₄O 
• 764649-63-0 (2R)-3-{[2-(4-chloro-2,5-difluorophenyl)-6-ethylpyrimidin-4-yl]amino}propane-1,2-diol oxalate 
• 1395553-37-3 2-(4-chloro-2,5-difluorophenyl)-6-methyl-N-[2-(1-oxidopyridin-3-yl)ethyl]pyrimidin-4-amine 
• 1395552-89-2 2-(4-chloro-2,5-difluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine 
• 1395552-94-9 2-(4-chloro-2,5-difluorophenyl)-6-ethyl-N-[2-(2-methoxypyridin-4-yl)ethyl]pyrimidin-4-amine 
• 794485-71-5 4-(2-{[2-(4-chloro-2,5-difluorophenyl)-6-methylpyrimidin-4-yl]amino}ethyl)pyridin-2(1H)-one 
• 795266-61-4 4-(2-{[2-(4-chloro-2,5-difluorophenyl)-6-ethylpyrimidin-4-yl]amino}ethyl)pyridin-2(1H)-one 
• 764649-62-9 (2R)-3-{[2-(4-chloro-2,5-difluorophenyl)-6-ethylpyrimidin-4-yl]amino}propane-1,2-diol 
• 135748-35-5 4-chloro-2,5-difluoro-benzonitrile 
• 764648-44-4 4-chloro-2,5-difluorobenzamidine 
• 764648-49-9 2-(4-chloro-2,5-difluorophenyl)-6-methylpyrimidin-4-one 
• 764648-50-2 2-(4-chloro-2,5-difluorophenyl)-6-ethylpyrimidin-4-one 

Relevant articles and documents

2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS

Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): (IA) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.