50838-61-4

Basic information

• Product Name: 3-(3,4-dimethoxyphenyl)-2-methylpropanal
• CAS NO: 50838-61-4
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.2536
• Mol File: 50838-61-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 294°C at 760 mmHg
• Flash Point: 122.4°C
• Density: 1.036g/cm³
• Vapor Pressure: 0.00167mmHg at 25°C
• Refractive Index: 1.494
• CAS DataBase Reference: 3-(3,4-dimethoxyphenyl)-2-methylpropanal(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-dimethoxyphenyl)-2-methylpropanal(50838-61-4)
• EPA Substance Registry System: 3-(3,4-dimethoxyphenyl)-2-methylpropanal(50838-61-4)

Safety Data

• Hazardous Substances Data: 50838-61-4(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 93-15-2 1,2-dimethoxy-4-(2-propenyl)benzene 
• 6379-72-2 1,2-dimethoxy-4-(E)-propenylbenzene 
• 714237-84-0 1-acetoxy-2-methyl-3-(3,4-dimethoxyphenyl)propene 

Relevant articles and documents

Micellar Catalysis for Sustainable Hydroformylation

It is here reported a fully sustainable and generally applicable protocol for the regioselective hydroformylation of terminal alkenes, using cheap commercially available catalysts and ligands, in mild reaction conditions (70 °C, 9 bar, 40 min). The process can take advantages from both micellar catalysis and microwave irradiation to obtain the linear aldehydes as the major or sole regioisomers in good to high yields. The substrate scope is largely explored as well as the application of hydroformylation in tandem with intramolecular hemiacetalization thus demonstrating the compatibility with a broad variety of functional groups. The reaction is efficient even in large scale and the catalyst and micellar water phase can be reused at least 5 times without any impact in reaction yields. The efficiency and sustainability of this protocol is strictly related to the in situ transformation of the aldehyde into the corresponding Bertagnini's salt that precipitates in the reaction mixture avoiding organic solvent mediated purification steps to obtain the final aldehydes as pure compounds.

Rhodium/Phosphine catalysed selective hydroformylation of biorenewable olefins

This work reports rhodium catalyzed selective hydroformylation of natural olefins like eugenol, estragole, anethole, prenol and isoprenol using biphenyl based Buchwald phosphine ligands (S-Phos (L1), t-Bu XPhos (L2), Ru-Phos (L3), Johnphos (L4) and DavePhos (L5). Ru-Phos (L3) ligand exhibited high impact on the hydroformylation of eugenol providing high selectivity (90%) of linear aldehyde as major product. In addition, internal natural olefins like anethole and prenol provided moderate to high selectivity (65% and 85% respectively) of branched aldehydes as a major products. The various reaction parameters such as influence of ligands, P/Rh ratio, syngas pressure, temperature, time and solvents have been studied. A high activity and selectivity gained on the way to the linear aldehydes it may be due to the bulky, steric cyclohexyl and isopropoxy groups present in L3 phosphine ligand. Moreover, this catalytic system was smoothly converting natural olefins into corresponding linear and branched aldehydes with higher selectivity under the mild reaction conditions.

Thermoregulated microemulsions by cyclodextrin sequestration: A new approach to efficient catalyst recovery

The use of imidazolium surfactants with cyclodextrins (CDs) as a control element in the thermoregulated olefin hydroformylation was reported. The 1-alkyl-3-methylimidazolium salts was used as surfactants for the rhodium-catalyzed hydroformylation reaction