50846-36-1

Basic information

• Product Name: 2-AMINO-2-METHYL-PROPIONITRILE HYDROCHLORIDE
• Synonyms: 2-AMINO-2-METHYL-PROPIONITRILE HYDROCHLORIDE;alpha-Aminoisobutyronitrile hydrochloride;2-AMino-2-Methylpropanenitrile HCl;Propanenitrile, 2-aMino-2-Methyl-, Monohydrochloride;2-AMino-2-Methylpropaneitrile hydrochloride
• CAS NO: 50846-36-1
• Molecular Formula: C₄H₈N₂*ClH
• Molecular Weight: 120.58
• EINECS: 1308068-626-2
• Mol File: 50846-36-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 147-149℃
• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-AMINO-2-METHYL-PROPIONITRILE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-2-METHYL-PROPIONITRILE HYDROCHLORIDE(50846-36-1)
• EPA Substance Registry System: 2-AMINO-2-METHYL-PROPIONITRILE HYDROCHLORIDE(50846-36-1)

Safety Data

• Hazardous Substances Data: 50846-36-1(Hazardous Substances Data)

Usage

General Description

2-Amino-2-methyl-propionitrile hydrochloride is a chemical compound with the molecular formula C4H9N2. It is a colorless to pale yellow liquid with a faint unpleasant odor and is soluble in water. 2-AMINO-2-METHYL-PROPIONITRILE HYDROCHLORIDE is commonly used as an intermediate in the production of various pharmaceuticals and agrochemicals. It is also utilized in organic synthesis as a building block for the preparation of other organic compounds. Additionally, 2-amino-2-methyl-propionitrile hydrochloride has the potential to be used as a reagent in the synthesis of new chemical entities for various applications in the chemical industry.

Upstream product

• 67-64-1 acetone 
• 19355-69-2 2-amino-2-cyanopropane 
• 151-50-8 potassium cyanide 

Downstream Products

• 16252-90-7 2-amino-2-methylpropanamide 
• 2582-16-3 2,2,5,5-tetramethylimidazolidine-4-thione 
• 100134-82-5 (cyano-dimethyl-methyl)carbamic acid benzyl ester 
• 1258444-79-9 (1R,2R,4R)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid (cyanodimethylmethyl)amide 
• 79662-84-3 (1-Cyan-1-methylethyl)harnstoff 
• 1026308-88-2 N-(1-cyano-1-methyl-ethyl)-4-methoxybenzamide 
• 1749-99-1 4-imino-5,5-dimethylimidazolidin-2-one 

Relevant articles and documents

Prebiotically Plausible Organocatalysts Enabling a Selective Photoredox α-Alkylation of Aldehydes on the Early Earth

Organocatalysis is a powerful approach to extend and (enantio-) selectively modify molecular structures. Adapting this concept to the Early Earth scenario offers a promising solution to explain their evolution into a complex homochiral world. Herein, we present a class of imidazolidine-4-thione organocatalysts, easily accessible from simple molecules available on an Early Earth under highly plausible prebiotic reaction conditions. These imidazolidine-4-thiones are readily formed from mixtures of aldehydes or ketones in presence of ammonia, cyanides and hydrogen sulfide in high selectivity and distinct preference for individual compounds of the resulting catalyst library. These organocatalysts enable the enantioselective α-alkylation of aldehydes under prebiotic conditions and show activities that correlate with the selectivity of their formation. Furthermore, the crystallization of single catalysts as conglomerates opens the pathway for symmetry breaking.

CATHEPSIN INHIBITORS

This invention relates to a novel class of compounds, represented by the formula (I) below, wherein the meanings of R1, R2, R3 and R4 are indicated therein, which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis, osteoarthritis and rheumatoid arthritis.

Preparation of α-aminothioamides from aldehydes

The conversion of aldehydes into α-aminonitriles and thence into imidazolidin-4-thiones has been studied.Hydrolysis of the appropriate imidazolidin-4-thiones gave thioamides of nine naturally occuring α-amino acids.The possible pre-biotic significance of these compounds is discussed.