509072-57-5Relevant articles and documents
Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups
Jeffries, Benjamin,Wang, Zhong,Troup, Robert I.,Goupille, Ana?s,Le Questel, Jean-Yves,Fallan, Charlene,Scott, James S.,Chiarparin, Elisabetta,Graton, Jér?me,Linclau, Bruno
supporting information, p. 2141 - 2150 (2021/02/05)
A systematic comparison of lipophilicity modulations upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl substituents, at a single carbon atom, is provided using directly comparable, and easily accessible model compounds. In addition, comparison with relevant linear chain derivatives is provided, as well as lipophilicity changes occurring upon chain extension of acyclic precursors to give cyclopropyl containing compounds. For the compounds investigated, fluorination of the isopropyl substituent led to larger lipophilicity modulation compared to fluorination of the cyclopropyl substituent.
COMPOUNDS AND THEIR METHODS OF USE
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Page/Page column 150, (2018/09/08)
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.
OXAZOLIDINONE HYDROXAMIC ACID COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS
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Page/Page column 124, (2015/05/19)
This invention pertains generally to treating bacterial infections using organic compounds of Formula I. In certain aspects, the invention pertains to treating infections caused by Gram-negative bacteria. (I) wherein X, Y, R1, R2, R3, R4 and R5 and defined herein.