51039-84-0

Basic information

• Product Name: 1-(2-NITROPHENYL)-2-THIOUREA
• Synonyms: 1-(2-NITROPHENYL)-2-THIOUREA;2-NITROPHENYLTHIOUREA;2-Nitrophenylthiourea, 98+%;1-(o-Nitrophenyl)thiourea;N-(2-Nitrophenyl)thiourea, 98+%;N-(2-Nitrophenyl)thiourea
• CAS NO: 51039-84-0
• Molecular Formula: C₇H₇N₃O₂S
• Molecular Weight: 197.21
• EINECS: -0
• Mol File: 51039-84-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 136 °C
• Boiling Point: 350.6 °C at 760 mmHg
• Flash Point: 165.8 °C
• Appearance: /
• Density: 1.524 g/cm³
• Vapor Pressure: 4.34E-05mmHg at 25°C
• Refractive Index: 1.759
• PKA: 12.01±0.70(Predicted)
• BRN: 2972327
• CAS DataBase Reference: 1-(2-NITROPHENYL)-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-NITROPHENYL)-2-THIOUREA(51039-84-0)
• EPA Substance Registry System: 1-(2-NITROPHENYL)-2-THIOUREA(51039-84-0)

Safety Data

• Statements: 25
• Safety Statements: 22-36/37-45
• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 51039-84-0(Hazardous Substances Data)

Usage

General Description

1-(2-Nitrophenyl)-2-thiourea is a chemical compound with the molecular formula C7H7N3O2S. It is a thiourea derivative with a nitrophenyl group attached to the nitrogen atom. 1-(2-NITROPHENYL)-2-THIOUREA has been studied for its potential applications in various fields, including medicinal chemistry and agriculture. It is known for its ability to form complexes with transition metal ions, making it useful for catalysis and coordination chemistry. Additionally, 1-(2-nitrophenyl)-2-thiourea has been investigated for its potential antibacterial and antifungal properties, indicating its potential for use as a pharmaceutical agent. Overall, this chemical compound has garnered attention for its diverse range of potential applications and is the subject of ongoing research.

InChI:InChI=1/C7H7N3O2S/c8-7(13)9-5-3-1-2-4-6(5)10(11)12/h1-4H,(H3,8,9,13)

Upstream product

• 66934-10-9 N-[[(2-nitrophenyl)amino]thioxomethyl]-benzamide 
• 1147550-11-5 ammonium thiocyanate 
• 88-74-4 2-nitro-aniline 
• 2719-30-4 o-nitrophenylisothiocyanate 

Downstream Products

• 20943-32-2 5-(2-nitro-anilino)-3H-thiazolo[4,5-d]thiazol-2-one 
• 82844-26-6 5,5-Bis-(2-hydroxy-phenyl)-3-(2-nitro-phenyl)-2-thioxo-imidazolidin-4-one 
• 1258978-19-6 1-[6-hydroxy-1-(2-hydroxyethyl)-4-oxo-1,4-dihydro[1,7]phenanthroline-3-carbonyl]-3-(2-nitrophenyl)thiourea 
• 70973-04-5 (2-nitro-phenyl)-guanidine 
• 1258978-07-2 1-[6-chloro-1-(2-hydroxyethyl)-4-oxo-1,4-dihydro[1,7]phenanthroline-3-carbonyl]-3-(2-nitrophenyl)thiourea 
• 1226644-68-3 C₂₅H₁₇ClF₃N₉O₃S₂ 
• 824944-53-8 N-[2-nitrophenyl]-4-(4-pyridinyl)-1,3-thiazol-2-amine 
• 1059176-86-1 C₂₄H₁₄ClF₃N₁₀O₄S₂ 
• 233-94-3 thiazolo[5,4-h]quinoline 
• 855283-00-0 2-chloro-benzothiazol-4-ylamine 
• 1123-51-9 4-aminobenzothiazol 

Relevant articles and documents

2-amino-4-nitrobenzothiazole

The crystal structure of the title compound, C7H5N3O2S, consists of centrosymmetric dimers, the principal intradimer interaction being two pairs of three-centre hydrogen bonds involving the amino group, the ring

Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds

Two series of compounds carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivatives. The biological results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series (compounds 2.6 and 4.6) on several cell lines tested. Moreover, our results point out an antiangiogenic activity of these compounds. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.

5-(4-hydroxyl-3-methoxyl benzylidene)-2-(2-nitryl phenylimino) thiazolidone and application

The invention discloses a compound 5-(4-hydroxyl-3-methoxyl benzylidene)-2-(2-nitryl phenylimino) thiazolidone, HMNT for short, and an application thereof in an aromatic hydrocarbon receptor stimulant, wherein the chemical structure is as shown in a formula (I). Experiments verify that the compound disclosed by the invention effectively causes up-regulation of genetic expression and protein expression of a metabolic enzyme CYP1A1 of a related allogenic material of a downstream target gene of an aromatic hydrocarbon receptor in a mouse hepatoma carcinoma cell at the concentration of 10 mu M and prompts that the compound is the aromatic hydrocarbon receptor stimulant, is expected to become a potential drug by taking the aromatic hydrocarbon receptor as a tumor treating target, and is wide in clinical application prospect.