51063-97-9

Basic information

• Product Name: 1,2-DISTEAROYL-RAC-GLYCEROL
• Synonyms: DL-ALPHA,BETA-DISTEARIN;DISTEARIN;DISTEARYOYLGLYCEROL;GLYCERYL DISTEARATE;GLYCEROL DISTEARATE;1,2-DISTEAROYL-RAC-GLYCEROL;1,2-DISTEARIN;1,2-DIOCTADECANOYL-RAC-GLYCEROL
• CAS NO: 51063-97-9
• Molecular Formula: C₃₉H₇₆O₅
• Molecular Weight: 625.02
• EINECS: 256-941-4
• Mol File: 51063-97-9.mol
• Article Data: 27

Chemical Properties

• Melting Point: 72-74 °C
• Boiling Point: 662.3 °C at 760 mmHg
• Flash Point: 181.8 °C
• Appearance: /
• Density: 0.923 g/cm³
• Storage Temp.: −20°C
• PKA: 13.69±0.10(Predicted)
• BRN: 1730305
• CAS DataBase Reference: 1,2-DISTEAROYL-RAC-GLYCEROL(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DISTEAROYL-RAC-GLYCEROL(51063-97-9)
• EPA Substance Registry System: 1,2-DISTEAROYL-RAC-GLYCEROL(51063-97-9)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 1
• Hazardous Substances Data: 51063-97-9(Hazardous Substances Data)

Usage

Uses

rac-1,2-Distearoylglycerol may be used for the in vitro assay for monoacylglycerol transferase (MGAT) and diacylglycerol acyltransferase (DGAT) activity.

General Description

rac-1,2-Distearoylglycerol is an 1,2-diacylglycerol.

InChI:InChI=1/C39H76O5/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(41)43-36-37(35-40)44-39(42)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h37,40H,3-36H2,1-2H3

Upstream product

• 555-43-1 glycerol tristearate 
• 96-13-9 2,3-Dibromopropan-1-ol 
• 822-16-2 sodium stearate 
• 56-81-5 glycerol 
• 132679-65-3 1-stearoyI-3-(tert-butyldimethylsilyl)-sn-glycerol 
• 22610-63-5 octadecanoic acid 2,3-dihydroxypropyl ester 
• 57-11-4 stearic acid 
• 112-61-8 Methyl stearate 
• 76189-95-2 3-O-benzyl-1,2-di-O-stearoyl-rac-glycerol 
• 69161-61-1 2-(prop-2-en-1-yloxy)oxane 
• 22128-25-2 rac-1-O-(tetrahydro-2H-pyran-2-yl)-glycerol 
• 110-87-2 3,4-dihydro-2H-pyran 
• 593-29-3 potassium stearate 
• 22128-27-4 Octadecanoic acid 1-octadecanoyloxymethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl ester 

Downstream Products

• 4537-76-2 distearylphosphatidylethanolamine 
• 504-40-5 1,3-distearoylglycerol 
• 20441-80-9 1,2-Di-O-stearoyl-glycerin-3-(O-benzyl-phosphit) <=O-Benzyl-O-(2,3-distearoyloxy-propyl)-phosphit> 
• 64350-15-8 Octadecanoic acid 1-octadecanoyloxymethyl-2-[phenylamino-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-ethyl ester 
• 816-94-4 {2-[(2,3-bis-stearoyloxy-propoxy)-hydroxy-phosphoryloxy]-ethyl}-trimethyl-ammonium betaine 
• 75257-05-5 (1,2-distearoyl-rac-3-glycero)-O-benzyl diethylamidophosphite 
• 75257-04-4 1,2-distearoylglycerol dibenzyl phosphite 
• 82878-44-2 O-(1,2-distearoyl-rac-3-glycero) O-(N-methyl-N-benzylaminoethyl) O-benzyl phosphite 
• 127931-28-6 1-decanoyloxy-2,3-bis-stearoyloxy-propane 
• 2442-53-7 α-Linoleoyl-β,α'-distearoin 
• 495399-43-4 3-(((4-nitrophenoxy)carbonyl)oxy)propane-1,2-diyl distearate 
• 671212-75-2 1,2-distearoyl phosphatidyl venlafaxine 
• 779335-19-2 1,2-distearoyl phosphatidyl atorvastatin 
• 64350-17-0 Octadecanoic acid 1-octadecanoyloxymethyl-2-{(2,2,2-trichloro-ethoxy)-[2-(trityl-amino)-ethoxy]-phosphoryloxy}-ethyl ester 

Relevant articles and documents

Synthesis of acylglycerol derivatives by mechanochemistry

In recent times, many biologically relevant building blocks such as amino acids, peptides, saccharides, nucleotides and nucleosides, etc. have been prepared by mechanochemical synthesis. However, mechanosynthesis of lipids by ball milling techniques has remained essentially unexplored. In this work, a multistep synthetic route to access mono- and diacylglycerol derivatives by mechanochemistry has been realized, including the synthesis of diacylglycerol-coumarin conjugates.

COMPOSITIONS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

1,2-Diacrylglycerol and wherein the intermediate preparation method

The invention discloses a preparation method for diacylglycero and an intermediate thereof. The preparation method for diacylglycero comprises the following steps: in an ether solvent and/or an alcohol solvent, in the present of an alkali, performing hydrolysis reaction on a compound shown as a formula 5, so as to obtain diacylglycero which is 1 shown in a formula 1. R in the formula 5 and 5 is C14-C18 saturated or unsaturated aliphatic acyl. The preparation method is cheap in raw materials, mild in reaction conditions, safe in operation, simple in postprocessing operation, high in reaction conversion rate, high in yield and suitable for large-scale production.