5107-81-3

Basic information

• Product Name: Acetamide, 2-(diethylamino)-N-[3-(trifluoromethyl)phenyl]-
• CAS NO: 5107-81-3
• Molecular Formula: C13H17F3N2O
• Molecular Weight: 274.286
• Mol File: 5107-81-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetamide, 2-(diethylamino)-N-[3-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2-(diethylamino)-N-[3-(trifluoromethyl)phenyl]-(5107-81-3)
• EPA Substance Registry System: Acetamide, 2-(diethylamino)-N-[3-(trifluoromethyl)phenyl]-(5107-81-3)

Safety Data

• Hazardous Substances Data: 5107-81-3(Hazardous Substances Data)

Upstream product

• 351-38-2 N-chloroacetyl-3-(trifluoromethyl)aniline 
• 109-89-7 diethylamine 

Relevant articles and documents

Synthesis and antispasmodic activity of lidocaine derivatives endowed with reduced local anesthetic action

The present structure-activity relationship (SAR) study focused on chemical modifications of the structure of the local anesthetic lidocaine, and indicated analogues having reduced anesthetic potency, but with superior potency relative to the prototype in preventing anaphylactic or histamine-evoked ileum contraction. From the SAR analysis, 2-(diethylamino)-N-(trifluoromethyl-phenyl) and 2-(diethylamino)-N-(dimethyl-phenyl) acetamides were selected as the most promising compounds. New insights into the applicability of non-anesthetic lidocaine derivatives as templates in drug discovery for allergic syndromes are provided.